| Evans' syndrome in pregnancy: a systematic literature review and two new cases. | |
| | |
MedLine Citation:
|
PMID: 20031296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Evans' syndrome, the coexistence of immune thrombocytopenia (ITP) with autoimmune haemolytic anaemia (AIHA), is rare in pregnancy, with a few published cases. Concerns about the teratogenic effect of pharmacological agents used in the management of Evans' syndrome limit the treatment options in pregnancy. In this paper we performed a systematic review of the literature of all published cases with Evans' syndrome in pregnancy and we report two new cases. The review was performed by searching the electronic databases PubMed, EMBASE, Cochrane Library and Google scholar up to the end of December 2008. The selection criteria were Evans' syndrome in pregnancy; autoimmune haemolytic anaemia; immune thrombocytopenia. Thirteen papers reporting 14 pregnancies in women with Evans' syndrome have been published: 7 papers are written in English. Evans' syndrome can be diagnosed with a full blood count, film and Coombs testing. It runs a more benign course in pregnancy than in non-pregnant state (notably neutropenia does not occur) and very often resolves post-delivery. The fetal outcome may be less favourable: a minority of fetuses are affected by transplacental passage of antibody and have a significant morbidity and mortality. With appropriate treatment, women with Evans' syndrome can have successful pregnancies, with a good response to conventional treatment. More detailed studies of Evans' syndrome in pregnancy, especially of fetal outcome, are required. |
| | |
Authors:
|
Eleftheria Lefkou; Catherine Nelson-Piercy; Beverley J Hunt |
Related Documents
:
|
19720336 - Pregnancy-associated breast cancer: significance of early detection. 17399946 - Favorable pregnancy outcome following trastuzumab (herceptin) use during pregnancy--cas... 19911296 - Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: ... 12955646 - Is a black-pigmented corynebacterium species an opportunistic pathogen during pregnancy... 819676 - The use of ultrasound in obstetrics and gynecology. 15993936 - Assessment of feto-placental well-being in the mare from mid-gestation to term: transre... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review Date: 2009-12-23 |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 149 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 10-7 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Haematology, Guy's & St. Thomas' NHS Foundation Trust, London SE1 7EH, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anemia, Hemolytic, Autoimmune / diagnosis, drug therapy* Coombs' Test Female Humans Immunoglobulin G / therapeutic use Prednisolone / therapeutic use Pregnancy Pregnancy Complications, Hematologic / diagnosis, drug therapy* Pregnancy Outcome Purpura, Thrombocytopenic, Idiopathic / diagnosis, drug therapy* Syndrome Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Health burden of co-morbid asthma and allergic rhinitis in West Indian children.
Next Document: A new approach to postoperative peritoneal adhesions: Prevention of peritoneal trauma by aloe vera g...