| Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. | |
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MedLine Citation:
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PMID: 19122058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and metabolic variables were evaluated in 14 Labrador retrievers with exercise-induced collapse (EIC) before, during, and following completion of a standardized strenuous exercise protocol. Findings were compared with previously reported variables from 14 normal Labrador retrievers that participated in the same protocol. Ten of 14 dogs with EIC developed an abnormal gait during evaluation, and these dogs were significantly more tachycardic and had a more severe respiratory alkalosis after exercise compared to the normal dogs. Muscle biopsy characteristics and sequential lactate and pyruvate concentrations were normal. Genetic testing and linkage analysis excluded malignant hyperthermia as the cause of EIC. Common causes of exercise intolerance were eliminated, but the cause of collapse in EIC was not determined. |
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Authors:
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Susan M Taylor; Cindy L Shmon; Vicki J Adams; James R Mickelson; Edward Ned E Patterson; G Diane Shelton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Animal Hospital Association Volume: 45 ISSN: 1547-3317 ISO Abbreviation: J Am Anim Hosp Assoc Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415027 Medline TA: J Am Anim Hosp Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 3-13 Citation Subset: IM |
Affiliation:
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Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopsy / veterinary Blood Chemical Analysis Body Temperature Carnitine / analysis, blood, urine Dog Diseases / genetics, physiopathology* Dogs / genetics, physiology* Female Male Malignant Hyperthermia / veterinary Physical Conditioning, Animal / adverse effects* Quadriceps Muscle / surgery Rest / physiology Ryanodine Receptor Calcium Release Channel / genetics |
| Chemical | |
Reg. No./Substance:
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0/Ryanodine Receptor Calcium Release Channel; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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