Document Detail

Evaluations of bioactivity and mechanical properties of poly (epsilon-caprolactone)/silica nanocomposite following heat treatment.
MedLine Citation:
PMID:  14762919     Owner:  NLM     Status:  MEDLINE    
A composite material consisting of poly(epsilon-caprolactone) (PCL) and silica was prepared and evaluated as a bioactive bone substitute. The composite was synthesized by the co-condensation of tetraethyl orthosilicate and PCL and end-capped with triethoxysilane (Si-PCL). The as-prepared specimens were subjected to an initial heat treatment of 2 days at 60 degrees C, followed by further heat-treatments at 100 degrees C, 150 degrees C, and 200 degrees C for 24 h. The tensile mechanical properties of the heat-treated specimens were determined, and additional specimens were exposed to a simulated body fluid (SBF) for different periods of time. The SBF exposure led to the deposition of a layer of apatite crystals on the surface of the composites. It was found that increasing the second heat-treatment temperature produced an increase in tensile strength and Young's modulus of the composite but a decrease in the initial rate of apatite formation. These phenomena are explained in terms of the condensation reaction that takes place between the silanol groups in the silica and Si-PCL as the heat-treatment temperature is increased.
Jeong Joon Yoo; Sang-Hoon Rhee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  68     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-05     Completed Date:  2004-10-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-10     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley Periodicals, Inc.
Department of Orthopedic Surgery, College of Medicine, Seoul National University Hospital, Seoul 110-744, Korea.
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MeSH Terms
Body Fluids
Bone Substitutes / chemical synthesis*,  standards
Composite Resins / chemical synthesis*,  standards
Hot Temperature
Silicon Dioxide*
Solutions / pharmacology
Tensile Strength
Reg. No./Substance:
0/Apatites; 0/Bone Substitutes; 0/Composite Resins; 0/Polyesters; 0/Solutions; 24980-41-4/polycaprolactone; 7631-86-9/Silicon Dioxide

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