Document Detail

Evaluation of wound-healing potential of Pisonia grandis R.Br: a preclinical study in Wistar rats.
MedLine Citation:
PMID:  18372265     Owner:  NLM     Status:  MEDLINE    
Pisonia grandis R.Br (family: Nyctaginaceae) is a herb claimed to be used for treatment of inflammation, wound healing, algesia, and ulcer. The present study was done to evaluate the wound-healing potential of methanolic extract of its leaves. Following preliminary photochemical evaluation, the extract was incorporated in simple ointment base and evaluated using 2 types of wound models in Wistar rats-excision wound and incision wound. The results were significantly different ( p <0.05) when compared with control group for wound contraction, tensile strength, and histopathological and biological parameters. Antibacterial studies against different bacterial strains of the test samples were performed by the disk-diffusion method and were compared with standard ofloxacin and erythromycin. Test sample showed comparable zone of inhibition to the standards. It is hypothesized that the presence of phytoconstituents with the antibacterial effect helps in wound healing.
D Prabu; M Nappinnai; K Ponnudurai; K Prabhu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of lower extremity wounds     Volume:  7     ISSN:  1534-7346     ISO Abbreviation:  Int J Low Extrem Wounds     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128359     Medline TA:  Int J Low Extrem Wounds     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Department of Pharmacology, C L Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India.
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MeSH Terms
Disease Models, Animal
Disk Diffusion Antimicrobial Tests
Plant Extracts*
Wound Healing / drug effects*
Reg. No./Substance:
0/Plant Extracts

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