Document Detail


Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs.
MedLine Citation:
PMID:  7480361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we established receptor binding assays to evaluate the water extracts of ten central nervous system (CNS)-active Chinese herbal drugs. These ten herbal drugs are Chaihu (Radix Bupleuri), Chuanxiong (Rhizoma Chuanxiong), Danggui (Radix Angelicae sinensis), Danshen (Radix Salviae miltiorrhizae), Duhuo (Radix Angelicae pubescentis), Hangqin (Radix Scutellariae), Qinjiao (Radix Gentianae macrophyllae), Shengma (Rhizoma Cimicifugae), Suanzaoren (Semen Zizphi spinose), and Yangjihua (Flos Daturae). The results indicated that these water extracts contained the principles acting on the dopamine (D1 & D2), muscarinice acetylcholine (M1), or 5-HT (5-HT1A & 5-HT2) receptors, or the benzodiazepine and the gamma-amino-n-butyric acid (GABA) binding sites of GABAA receptors as determined by receptor binding assays. The receptors or binding sites which predominantly acted by each water extract are listed as follows: Chaihu: D2, 5-HT1A, GABA; Chuanxiong: GABA, 5-HT1A; Danggui: GABA, 5-HT1A; Danshen: BDZ; Duhuo: GABA, 5-HT1A, D2, D1; Hangqin: BDZ, D1, 5-HT1A; Qinjiao: GABA, BDZ, 5-HT1A, D2; Shengma: 5-HT1A; Suanzaoren: 5-HT1A, 5-HT2, GABA; Yangjihua: M1, 5-HT1A, 5-HT2. These results provided evidence to explain the CNS effects of these herbal drugs at the receptor level. Furthermore, these results provided information to direct the isolation and purification of receptor-interactive compounds from these herbal drugs.
Authors:
J F Liao; Y M Jan; S Y Huang; H H Wang; L L Yu; C F Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Science Council, Republic of China. Part B, Life sciences     Volume:  19     ISSN:  0255-6596     ISO Abbreviation:  Proc. Natl. Sci. Counc. Repub. China B     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-07     Completed Date:  1995-12-07     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  8502426     Medline TA:  Proc Natl Sci Counc Repub China B     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Cerebral Cortex / metabolism*
Corpus Striatum / metabolism*
Drugs, Chinese Herbal / metabolism*
Male
Mice
Mice, Inbred ICR
Receptors, Cell Surface / metabolism*
Receptors, Dopamine D1 / metabolism
Receptors, Dopamine D2 / metabolism
Receptors, GABA / metabolism
Receptors, Muscarinic / metabolism
Receptors, Serotonin / metabolism
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Receptors, Cell Surface; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Receptors, GABA; 0/Receptors, Muscarinic; 0/Receptors, Serotonin

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