| Evaluation of ventilatory therapy for acid aspiration. | |
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MedLine Citation:
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PMID: 1166414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspiration of hydrochloric acid in experimental animals results in severe, progressive hypoxia which is due to intrapulmonary shunting and depressed cardiac output. This preparation is useful therefore in studying the therapy of hypoxia. Mongrel dogs were subjected to acid aspiration and the effects of several ventilatory patterns on intrapulmonary shunt fractions and lung water accumulation observed. The combination of large tidal volumes (30 c.c. per kilogram) with positive end-expiratory pressure was effective in preventing intrapulmonary shunting and other ventilatory patterns were ineffective. Pulmonary edema uniformly followed acid aspiration and was not affected by ventilatory therapy. When ventilatory therapy was delayed for 4 hours, the progression of shunting apparently was limited, but the existing shunt was not reduced. |
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Authors:
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L Flint; G Gosdin; C J Carrico |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery Volume: 78 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1975-12-11 Completed Date: 1975-12-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 492-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / etiology, therapy* Body Water / analysis Dogs Female Hydrochloric Acid Inhalation Lung / analysis Male Methods Pulmonary Edema / therapy* Respiration Respiration, Artificial* Tidal Volume Time Factors |
| Chemical | |
Reg. No./Substance:
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7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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