Document Detail

Evaluation of ventilatory therapy for acid aspiration.
MedLine Citation:
PMID:  1166414     Owner:  NLM     Status:  MEDLINE    
Aspiration of hydrochloric acid in experimental animals results in severe, progressive hypoxia which is due to intrapulmonary shunting and depressed cardiac output. This preparation is useful therefore in studying the therapy of hypoxia. Mongrel dogs were subjected to acid aspiration and the effects of several ventilatory patterns on intrapulmonary shunt fractions and lung water accumulation observed. The combination of large tidal volumes (30 c.c. per kilogram) with positive end-expiratory pressure was effective in preventing intrapulmonary shunting and other ventilatory patterns were ineffective. Pulmonary edema uniformly followed acid aspiration and was not affected by ventilatory therapy. When ventilatory therapy was delayed for 4 hours, the progression of shunting apparently was limited, but the existing shunt was not reduced.
L Flint; G Gosdin; C J Carrico
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  78     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-12-11     Completed Date:  1975-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-8     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / etiology,  therapy*
Body Water / analysis
Hydrochloric Acid
Lung / analysis
Pulmonary Edema / therapy*
Respiration, Artificial*
Tidal Volume
Time Factors
Reg. No./Substance:
7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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