Document Detail


Evaluation of vascular compliance and vasoconstrictive reactions in amputated hindlimbs of rats.
MedLine Citation:
PMID:  7602399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vascular compliance and the contractility of vascular smooth muscle of preserved, amputated hindlimbs of rats were evaluated using a fresh blood extracorporeal circulatory system. Vascular compliance was measured under physiologic circulatory conditions (blood pressure of the amputated limb was maintained at 80-150 mm Hg [10-20 kPa]) and found not to differ significantly from that of freshly amputated limbs after storage at 4 degrees C for 12 hours. However, after more than 24 hours of storage at 4 degrees C, the vascular compliance decreased significantly (p < 0.01). To evaluate the contractility of vascular smooth muscle, the arterial blood pressure in the amputated limbs was transiently increased with injections of norepinephrine. The contractility could be preserved for at least 12 hours at 4 degrees C; however, it decreased markedly after more than 24 hours. The vascular compliance and vasoconstrictive reactions of the amputated limbs were maintained for at least 12 hours at 4 degrees C.
Authors:
H Ono; Y Nakagawa; S Mizumoto; N Tomita; S Tamai
Related Documents :
15937199 - Advances in wound healing: topical negative pressure therapy.
11488719 - Collagenous and elastotic marginal plaques of the hands.
7769739 - The effects of elevated compartment pressure on tibial arteriovenous flow and relations...
974569 - Control of distension of varicose veins achieved by leg bandages, as used after injecti...
14601819 - Physical properties of short-stretch compression bandages used to treat lymphedema.
16163089 - Interface dressings influence the delivery of topical negative-pressure therapy.
17446399 - Synthesis of ultra-incompressible superhard rhenium diboride at ambient pressure.
3258359 - Risk factors for hypertension: results from a cross-sectional survey.
2582599 - Morphometric analyses of rabbit thoracic aorta after poststenotic dilatation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  13     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-09     Completed Date:  1995-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Nara Medical University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amputation*
Animals
Blood Pressure / drug effects
Blood Vessels / drug effects,  physiopathology
Hindlimb / blood supply*,  surgery*
Male
Norepinephrine / pharmacology
Rats
Rats, Inbred F344
Vascular Resistance*
Vasoconstriction*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reperfusion injury in vascularized bone allografts.
Next Document:  Comparison of the effect of reamed and unreamed locked intramedullary nailing on blood flow in the c...