Document Detail

Evaluation of vascular compliance and vasoconstrictive reactions in amputated hindlimbs of rats.
MedLine Citation:
PMID:  7602399     Owner:  NLM     Status:  MEDLINE    
The vascular compliance and the contractility of vascular smooth muscle of preserved, amputated hindlimbs of rats were evaluated using a fresh blood extracorporeal circulatory system. Vascular compliance was measured under physiologic circulatory conditions (blood pressure of the amputated limb was maintained at 80-150 mm Hg [10-20 kPa]) and found not to differ significantly from that of freshly amputated limbs after storage at 4 degrees C for 12 hours. However, after more than 24 hours of storage at 4 degrees C, the vascular compliance decreased significantly (p < 0.01). To evaluate the contractility of vascular smooth muscle, the arterial blood pressure in the amputated limbs was transiently increased with injections of norepinephrine. The contractility could be preserved for at least 12 hours at 4 degrees C; however, it decreased markedly after more than 24 hours. The vascular compliance and vasoconstrictive reactions of the amputated limbs were maintained for at least 12 hours at 4 degrees C.
H Ono; Y Nakagawa; S Mizumoto; N Tomita; S Tamai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  13     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-09     Completed Date:  1995-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Department of Orthopaedic Surgery, Nara Medical University, Japan.
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MeSH Terms
Blood Pressure / drug effects
Blood Vessels / drug effects,  physiopathology
Hindlimb / blood supply*,  surgery*
Norepinephrine / pharmacology
Rats, Inbred F344
Vascular Resistance*
Reg. No./Substance:

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