Document Detail


Evaluation and validation of microsphere technique for determination of pancreatic blood flow.
MedLine Citation:
PMID:  8214079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the radiolabeled microsphere technique for pancreatic blood flow measurements. Using a canine model with an isolated pancreatic circulation, we assessed the shunting of 11- and 15-microns-diam microspheres in the pancreas, correlated pancreatic blood flow measurements obtained with the microsphere technique with those made with an ultrasonic flow probe, and determined the effects of high doses of microspheres on pancreatic blood flow and its measurement. Microspheres of 11 microns demonstrate significant shunting through the pancreatic microcirculation with underestimation of pancreatic blood flow of approximately 10% compared with results obtained with 15-microns microspheres. There is a close linear relationship between flow results obtained with 15-microns microspheres and with an ultrasonic flow probe for both the resting (r = 0.85) and the secretin-stimulated pancreas (r = 0.97). Left atrial injections of very large doses of 15-microns microspheres (50 x 10(6)) caused an acute transient reduction of pancreatic blood flow (to 39% of baseline flow) with a return to baseline values within 2 min. The accuracy of flow results and absence of physiological changes after repeated injections support the use of 15-microns microspheres for pancreatic blood flow measurements.
Authors:
W Harringer; C Fernandez-del Castillo; D W Rattner; J L Guerrero; A L Warshaw; G J Vlahakes
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G587-94     Citation Subset:  IM    
Affiliation:
Department of Surgery, Harvard Medical School, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Evaluation Studies as Topic
Female
Male
Microspheres*
Pancreas / blood supply*,  ultrasonography
Particle Size
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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