| Evaluation and validation of microsphere technique for determination of pancreatic blood flow. | |
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MedLine Citation:
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PMID: 8214079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the radiolabeled microsphere technique for pancreatic blood flow measurements. Using a canine model with an isolated pancreatic circulation, we assessed the shunting of 11- and 15-microns-diam microspheres in the pancreas, correlated pancreatic blood flow measurements obtained with the microsphere technique with those made with an ultrasonic flow probe, and determined the effects of high doses of microspheres on pancreatic blood flow and its measurement. Microspheres of 11 microns demonstrate significant shunting through the pancreatic microcirculation with underestimation of pancreatic blood flow of approximately 10% compared with results obtained with 15-microns microspheres. There is a close linear relationship between flow results obtained with 15-microns microspheres and with an ultrasonic flow probe for both the resting (r = 0.85) and the secretin-stimulated pancreas (r = 0.97). Left atrial injections of very large doses of 15-microns microspheres (50 x 10(6)) caused an acute transient reduction of pancreatic blood flow (to 39% of baseline flow) with a return to baseline values within 2 min. The accuracy of flow results and absence of physiological changes after repeated injections support the use of 15-microns microspheres for pancreatic blood flow measurements. |
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Authors:
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W Harringer; C Fernandez-del Castillo; D W Rattner; J L Guerrero; A L Warshaw; G J Vlahakes |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 265 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-11-23 Completed Date: 1993-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G587-94 Citation Subset: IM |
Affiliation:
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Department of Surgery, Harvard Medical School, Boston, Massachusetts. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Evaluation Studies as Topic Female Male Microspheres* Pancreas / blood supply*, ultrasonography Particle Size Regional Blood Flow |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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