Document Detail

Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results.
MedLine Citation:
PMID:  15586629     Owner:  NLM     Status:  MEDLINE    
Adoption of standard input function (SIF) has been proposed for kinetic analysis of receptor binding potential (BP), instead of invasive frequent arterial samplings. The purpose of this study was to assess the SIF method in quantitative analysis of [123I]iomazenil (IMZ), a central benzodiazepine antagonist, for SPECT. SPECT studies were performed on 10 patients with cerebrovascular disease or Alzheimer disease. Intermittent dynamic SPECT scans were performed from 0 to 201 min after IMZ-injection. BPs calculated from SIFs obtained from normal volunteers (BPs) were compared with those of individual arterial samplings (BPo). Good correlations were shown between BP(o)s and BP(s)s in the 9 subjects, but maximum BP(s)s were four times larger than the corresponding BP(o)s in one case. There were no abnormal laboratory data in this patient, but the relative arterial input count in the late period was higher than the SIF. Simulation studies with modified input functions revealed that height in the late period can produce significant errors in estimated BPs. These results suggested that the simplified method with one-point arterial sampling and SIF can not be applied clinically. One additional arterial sampling in the late period may be useful.
Yujiro Seike; Kazuo Hashikawa; Naohiko Oku; Hiroshi Moriwaki; Haruko Yamamoto; Kazuki Fukuchi; Yoshiyuki Watanabe; Masayasu Matsumoto; Masatsugu Hori; Tsunehiko Nishimura
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Validation Studies    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  18     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-09     Completed Date:  2005-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  563-72     Citation Subset:  IM    
Strokology Medical Department, Bobath Memorial Hospital, Osaka, Japan.
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MeSH Terms
Alzheimer Disease / blood,  radionuclide imaging*
Brain / metabolism,  radionuclide imaging*
Cerebrovascular Disorders / blood,  radionuclide imaging*
Epilepsy / blood,  radionuclide imaging*
Flumazenil / analogs & derivatives*,  blood,  diagnostic use*,  pharmacokinetics
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Radioisotope Dilution Technique
Radiopharmaceuticals / blood,  diagnostic use,  pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods
Reg. No./Substance:
0/Radiopharmaceuticals; 127396-36-5/iomazenil; 78755-81-4/Flumazenil

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