Document Detail

Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy.
MedLine Citation:
PMID:  20850734     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the performance of a one-step test detecting intact hCG and free β-hCG isoforms in the urine of pregnant women to diagnose an abnormal pregnancy.
DESIGN: Prospective study.
SETTING: Emergency gynecology departments in teaching hospitals.
PATIENT(S): Five hundred twenty-six patients were enrolled, 272 who were not pregnant and 254 who were pregnant.
INTERVENTION(S) AND MAIN OUTCOME MEASURE(S): Semiquantitative determination of intact urinary hCG of supposedly not pregnant and pregnant women with vaginal bleeding and/or vaginal pain between 5 and 8 weeks of amenorrhea.
RESULT(S): The sensitivity and specificity of the urine test for diagnosing nonpregnancy were, respectively, 100% (252/252) and 100% (272/272). The sensitivity and specificity of the urine test for diagnosing ectopic pregnancy (EP) were, respectively, 97% (32/33) and 83% (142/171). The negative predictive value is 99.3% (142/143). The sensitivity and specificity or the urine test for diagnosing miscarriage were, respectively, 89.6% (43/48) and 83% (142/171). The negative predictive value is 96.6% (142/147).
CONCLUSION(S): Abnormal pregnancy, such as an EP or a miscarriage, can be rapidly detected with the one-step test for intact hCG and free β-hCG isoforms. If ultrasound cannot confirm the localization and/or evolution of a pregnancy, using this test reduces medical supervision and repeated quantification of hCG.
Silhem Mazouz; Jae Kwan Lee; Hervé Fernandez
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-09-20
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-02-28     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  783-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Abortion, Spontaneous / diagnosis,  urine*
Diagnostic Techniques, Obstetrical and Gynecological*
Embryo Loss / diagnosis,  urine
Fetal Development / physiology
Pregnancy Tests
Pregnancy Trimester, First / urine
Pregnancy, Ectopic / diagnosis,  urine*
Sensitivity and Specificity
Urinalysis / instrumentation,  methods*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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