| Evaluation of urinary bladder function after acute spinal cord injury: an experimental study. | |
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MedLine Citation:
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PMID: 20632928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to evaluate the efficacy of early surgical decompression of acute spinal cord injury through the evaluation of urinary bladder function in rabbits. MATERIALS AND METHODS: The study was done with 21 New Zealand male rabbits which were 9 to 12 months in age, and weighed an average of 2438 grams (range 2150 to 3550 g). The animals were assigned into four groups as follows: a control group (n=5), a laminectomy group (n=6), a 15-second compression group (n=5) and a 60-second compression group (n=5). A 60 gram compression force was applied on both compression groups with aneurysm clips. All rabbits were sacrificed seven days postoperatively. Urinary bladder tissues were dissected and in vitro relaxation and contraction tests were performed in organ baths. RESULTS: At the beginning of each experiment, 80 mM KCl was added to the isolated organ bath with no significant difference among all four groups (p>0.05). Carbachol was then added to the organ bath and contraction responses were obtained. Carbachol contraction responses were calculated as the percentage of the 80 mM KCl contraction responses, with compression groups showing significant difference from control and sham-operated groups (p<0.05). Electrical field stimulation responses were obtained for all group preparations at 4, 8, 16, 32 Hz frequencies, and showed significant difference in the 15 and 60-second compression groups (p<0.05). The contractility was assessed using E-max and pD2 values. All groups exhibited same pD2 values. CONCLUSION: The study demonstrated a slightly better outcome for bladder contractility with early decompression. However, there was no significant difference between early and delayed decompression groups. |
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Authors:
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Zekeriya Oztemür; Gündüz Tezeren; Ihsan Bağcivan; Bülent Saraç; Nedim Durmuş; Reyhan Eğilmez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery Volume: 21 ISSN: 1309-0313 ISO Abbreviation: Eklem Hastalik Cerrahisi Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265191 Medline TA: Eklem Hastalik Cerrahisi Country: Turkey |
Other Details:
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Languages: eng Pagination: 110-5 Citation Subset: IM |
Affiliation:
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Department of Orthopedics and Traumatology, Cumhuriyet University, Sivas, Turkey. oztemur@cumhuriyet.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / pharmacology Laminectomy Male Muscle Contraction / drug effects Potassium Chloride / pharmacology Rabbits Reference Values Spinal Cord Injuries / physiopathology*, surgery Stress, Mechanical Urinary Bladder / physiopathology*, surgery |
| Chemical | |
Reg. No./Substance:
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51-83-2/Carbachol; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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