Document Detail

Evaluation of urinary bladder function after acute spinal cord injury: an experimental study.
MedLine Citation:
PMID:  20632928     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to evaluate the efficacy of early surgical decompression of acute spinal cord injury through the evaluation of urinary bladder function in rabbits. MATERIALS AND METHODS: The study was done with 21 New Zealand male rabbits which were 9 to 12 months in age, and weighed an average of 2438 grams (range 2150 to 3550 g). The animals were assigned into four groups as follows: a control group (n=5), a laminectomy group (n=6), a 15-second compression group (n=5) and a 60-second compression group (n=5). A 60 gram compression force was applied on both compression groups with aneurysm clips. All rabbits were sacrificed seven days postoperatively. Urinary bladder tissues were dissected and in vitro relaxation and contraction tests were performed in organ baths. RESULTS: At the beginning of each experiment, 80 mM KCl was added to the isolated organ bath with no significant difference among all four groups (p>0.05). Carbachol was then added to the organ bath and contraction responses were obtained. Carbachol contraction responses were calculated as the percentage of the 80 mM KCl contraction responses, with compression groups showing significant difference from control and sham-operated groups (p<0.05). Electrical field stimulation responses were obtained for all group preparations at 4, 8, 16, 32 Hz frequencies, and showed significant difference in the 15 and 60-second compression groups (p<0.05). The contractility was assessed using E-max and pD2 values. All groups exhibited same pD2 values. CONCLUSION: The study demonstrated a slightly better outcome for bladder contractility with early decompression. However, there was no significant difference between early and delayed decompression groups.
Zekeriya Oztemür; Gündüz Tezeren; Ihsan Bağcivan; Bülent Saraç; Nedim Durmuş; Reyhan Eğilmez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery     Volume:  21     ISSN:  1309-0313     ISO Abbreviation:  Eklem Hastalik Cerrahisi     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265191     Medline TA:  Eklem Hastalik Cerrahisi     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  110-5     Citation Subset:  IM    
Department of Orthopedics and Traumatology, Cumhuriyet University, Sivas, Turkey.
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MeSH Terms
Carbachol / pharmacology
Muscle Contraction / drug effects
Potassium Chloride / pharmacology
Reference Values
Spinal Cord Injuries / physiopathology*,  surgery
Stress, Mechanical
Urinary Bladder / physiopathology*,  surgery
Reg. No./Substance:
51-83-2/Carbachol; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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