| Evaluation of two over-the-counter natural thyroid hormone preparations in human volunteers. | |
| | |
MedLine Citation:
|
PMID: 1576386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the pharmacologic activity of over-the-counter (OTC) thyroid preparations. DESIGN: In vitro analysis and a prospective, crossover study in vivo. SETTING: Tertiary care center. PARTICIPANTS: Two healthy adult volunteers. INTERVENTION: Three OTC preparations (Thyrotrophin PMG [bovine thyroid PMG extract], Thyro Forte [thyroid lymphogland concentrate with synergistic complex], and Thyro Complex [thyroid lyophilized gland concentrate with synergistic complex]) were analyzed in vitro. Volunteers were administered two times the manufacturer's maximum recommended daily dose of either Thyrotrophin PMG or Thyro Forte for one week, washed out for four to five weeks, and crossed over to receive the opposite tablet preparation for an additional week. MAIN OUTCOME MEASURES: The triiodothyronine (T3) and thyroxine (T4) contents of OTC preparations were measured by HPLC. Vital signs, serum total and free T4, total T3, thyroid stimulating hormone, thyroxine binding globulin, thyroglobulin, and general chemistry tests (including glucose and cholesterol) were monitored before, during, and between administration of the products. RESULTS: HPLC analysis of the three OTC preparations showed no T4 but did show possible T3 in two of these products. We found no definite clinical or laboratory evidence of thyroid hormone excess with either product. CONCLUSIONS: Healthcare professionals should advise against the use of these scientifically unsound and relatively expensive OTC thyroid preparations, of which the therapeutic efficacy is unknown. |
| | |
Authors:
|
G Csako; D M Corso; J Kestner; A D Bokser; P E Kennedy; F Pucino |
Related Documents
:
|
1252776 - Thyroid disease and sebaceous function. 20018826 - Low serum free triiodothyronine levels mark familial longevity: the leiden longevity st... 196716 - Suppression of radioiodide accumulation by the thyroids and oocytes of japanese quail w... 6372346 - Simple and sensitive method for estimation of antithyroid plasma membrane antibodies in... 3088906 - Alterations of urinary carbon dioxide tension, electrolyte handling and low molecular w... 3359696 - Dialysis-induced change in erythrocyte volume: effect on change in blood volume calcula... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 492-4 Citation Subset: IM |
Affiliation:
|
Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Drug Evaluation Humans Nonprescription Drugs* Tablets Thyroglobulin / blood Thyroid Hormones / administration & dosage, chemistry, pharmacology* Thyrotropin / blood Thyroxine / analysis Thyroxine-Binding Proteins / analysis Triiodothyronine / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Nonprescription Drugs; 0/Tablets; 0/Thyroid Hormones; 0/Thyroxine-Binding Proteins; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inadequate adrenergic response to disopyramide-induced hypoglycemia.
Next Document: In vitro delivery of crushed ciprofloxacin through a feeding tube.