Document Detail


Evaluation of two biological markers combined as a parameter of alcohol dependency.
MedLine Citation:
PMID:  9463727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detecting alcohol-dependent patients in a surgical ward. The performance of the combined test was significantly better than that of either %CDT alone or GT alone, as evaluated by calculating sensitivity and likelihood ratio at a specificity of 0.85 and by comparing areas under receiver-operating characteristic curves statistically. Improved performance was found for the whole group of patients, for men, for patients older than 35 years of age, and for those patients consuming more than 60 g alcohol per day. The performance of %CDT alone was similar to that of GT, %CDT being better in the age group 35-50 years, whereas GT was better for those drinking less than 60 g per day and for the oldest patients (> 50 years). Neither of the two tests or their combination performed well for patients younger than 36 years of age.
Authors:
N E Huseby; O Nilssen; R D Kanitz
Related Documents :
22038617 - Cardiac arrest after spinal anesthesia in a patient with neurally mediated syncope.
8667467 - Carbohydrate-deficient transferrin for identification of drug overdose patients at risk...
19939747 - Inflammation in achromobacter xylosoxidans infected cystic fibrosis patients.
8366507 - Arthropathies of cystic fibrosis: case reports and review of the literature.
1378047 - Development of urethral stricture after transurethral prostatectomy: a retrospective st...
22666737 - Clinical and laboratory features of children and adolescents with congenital hypothyroi...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  32     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-04-03     Completed Date:  1998-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  731-7     Citation Subset:  IM    
Affiliation:
Institute of Medical Biology, University of Tromsø, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / metabolism
Alcoholism / blood,  diagnosis*
Biological Markers / blood*
Female
Humans
Male
Middle Aged
Reproducibility of Results
Transferrin / analogs & derivatives*,  analysis,  metabolism
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin; EC 2.3.2.2/gamma-Glutamyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Screening for psychiatric comorbidity among female alcoholics: the use of a questionnaire (SCL-90) a...
Next Document:  Changes in human serum alcohol dehydrogenase activity during retinoic acid treatment of cancer patie...