Document Detail

Evaluation of two biological markers combined as a parameter of alcohol dependency.
MedLine Citation:
PMID:  9463727     Owner:  NLM     Status:  MEDLINE    
A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detecting alcohol-dependent patients in a surgical ward. The performance of the combined test was significantly better than that of either %CDT alone or GT alone, as evaluated by calculating sensitivity and likelihood ratio at a specificity of 0.85 and by comparing areas under receiver-operating characteristic curves statistically. Improved performance was found for the whole group of patients, for men, for patients older than 35 years of age, and for those patients consuming more than 60 g alcohol per day. The performance of %CDT alone was similar to that of GT, %CDT being better in the age group 35-50 years, whereas GT was better for those drinking less than 60 g per day and for the oldest patients (> 50 years). Neither of the two tests or their combination performed well for patients younger than 36 years of age.
N E Huseby; O Nilssen; R D Kanitz
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  32     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-04-03     Completed Date:  1998-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  731-7     Citation Subset:  IM    
Institute of Medical Biology, University of Tromsø, Norway.
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MeSH Terms
Aged, 80 and over
Aging / metabolism
Alcoholism / blood,  diagnosis*
Biological Markers / blood*
Middle Aged
Reproducibility of Results
Transferrin / analogs & derivatives*,  analysis,  metabolism
gamma-Glutamyltransferase / blood*
Reg. No./Substance:
0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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