Document Detail

Evaluation of tumor marker S-100 in cerebrospinal fluid from subjects with nonischemic brain pathologies.
MedLine Citation:
PMID:  10601840     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the S-100 concentration in cerebrospinal fluid from subjects with nonischemic brain damage, a total of 33 samples were analyzed: 11 from subjects in whom no organic disease could be found; 14 from patients with a diagnosis of lymphocytic or bacterial-fungal meningitis, and 8 from patients with acute lymphatic leukemia but no demonstrable signs of meningeal involvement. In all cases, the subjects considered had no previous history of melanoma or ischemic brain damage. The mean levels +/- SEM found for each study group were 1.00 +/- 0.11, 1.67 +/- 0.23 and 1.17 +/- 0.14 microg/l, respectively. Significant differences appeared between the groups when applying the Kruskal-Wallis nonparametric test (p = 0.035). The highest levels were found in the meningitis group and were significantly different from those of the control group (p = 0.015). No significant differences were found with regard to age or sex. Based on the pathophysiology of meningitis and on previous studies, the results suggest the existence of brain damage caused by an infection as a possible cause of increased S-100 levels.
J R Infante; M Torres-Avisbal; A Martinez; J A Vallejo; C Aguilera; P Contreras; A Benitez; J M Latre
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  21     ISSN:  1010-4283     ISO Abbreviation:  Tumour Biol.     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  38-45     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Nuclear Medicine, Hospital U. Reina Sofía, Córdoba, Spain.
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MeSH Terms
Age Factors
Meningitis, Bacterial / cerebrospinal fluid*,  pathology
Meningitis, Fungal / cerebrospinal fluid*,  pathology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / cerebrospinal fluid*,  pathology
Retrospective Studies
S100 Proteins / cerebrospinal fluid*
Sex Factors
Tumor Markers, Biological / cerebrospinal fluid*
Reg. No./Substance:
0/S100 Proteins; 0/Tumor Markers, Biological

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