Document Detail

Evaluation of trophoblast invasion in placental bed biopsies of the baboon, with immunohistochemical localisation of cytokeratin, fibronectin, and laminin.
MedLine Citation:
PMID:  8906606     Owner:  NLM     Status:  MEDLINE    
Biopsies of placentas (n = 21), placental bed (n = 17) and decidua (n = 26) of various gestation periods (30 to 140 days) were used to study trophoblast invasion in the baboon. Application of immunohistochemical staining for cytokeratin allowed proper identification of trophoblast. Earlier reports showing restricted trophoblast invasion in this species were confirmed by the finding that endovascular trophoblast was present in only one third of biopsies containing spiral arteries. Moreover, immunostaining for cytokeratin revealed that in several arteries only a few isolated trophoblastic cells were present, while the vessel had not undergone the normal physiological change. Trophoblast invasion could only be detected within decidual, but not in myometrial, segments of spiral arteries. Interstitial trophoblast invasion was very limited and multinuclear giant cells were absent. Immunohistochemical staining suggested a contribution of laminin to the fibrinoid deposition within the physiologically changed spiral arteries, while fibronectin was present intracellularly in the invaded trophoblast. Because of differences in the trophoblast invasion pattern, the baboon cannot be regarded as a satisfactory experimental model to explore results of inadequate endovascular trophoblast invasion which, in the human, leads to pregnancy complications such a preeclampsia.
R Pijnenborg; T D'Hooghe; L Vercruysse; C Bambra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical primatology     Volume:  25     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  272-81     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, Belgium.
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MeSH Terms
Arteries / cytology,  physiology
Biological Markers
Decidua / cytology,  physiology
Fibronectins / analysis
Keratins / analysis
Laminin / analysis
Models, Biological
Muscle, Smooth, Vascular / cytology,  physiology
Placenta / blood supply,  cytology,  physiology*
Trophoblasts / cytology,  physiology*
Reg. No./Substance:
0/Biological Markers; 0/Fibronectins; 0/Laminin; 68238-35-7/Keratins

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