| Evaluation and treatment of seizures in patients with systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 19078099 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Seizures associated with systemic lupus erythematosus (SLE) occur in 9 to 58% of patients in reported series, often early in the disease course. Approximately half of seizures reported in SLE patients are associated with infection and with metabolic or iatrogenic complications. However, in clinical practice, this number might be much larger, as relatively few prospective studies are available. The seizure type in nearly 75% of SLE patients is generalized tonic-clonic. These often begin with and recur, even without anticonvulsant treatment, only during an SLE disease flare. In contrast, seizures in SLE patients with a focal onset often recur without anticonvulsant treatment, irrespective of SLE disease activity. This review offers a practical diagnostic and management approach to the SLE patient with new or recurrent seizures and takes into consideration the effects of immunosuppressive therapy and multi-organ failure. This approach is based on a synthesis of the literature regarding seizures and epilepsy in SLE patients and on the authors' personal experience. |
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Authors:
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B Mayes; R L Brey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 2 ISSN: 1076-1608 ISO Abbreviation: J Clin Rheumatol Publication Date: 1996 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 336-45 Citation Subset: - |
Affiliation:
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University of Texas Health Science Center at San Antonio, San Antonio, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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