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Evaluation and treatment of seizures in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  19078099     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Seizures associated with systemic lupus erythematosus (SLE) occur in 9 to 58% of patients in reported series, often early in the disease course. Approximately half of seizures reported in SLE patients are associated with infection and with metabolic or iatrogenic complications. However, in clinical practice, this number might be much larger, as relatively few prospective studies are available. The seizure type in nearly 75% of SLE patients is generalized tonic-clonic. These often begin with and recur, even without anticonvulsant treatment, only during an SLE disease flare. In contrast, seizures in SLE patients with a focal onset often recur without anticonvulsant treatment, irrespective of SLE disease activity. This review offers a practical diagnostic and management approach to the SLE patient with new or recurrent seizures and takes into consideration the effects of immunosuppressive therapy and multi-organ failure. This approach is based on a synthesis of the literature regarding seizures and epilepsy in SLE patients and on the authors' personal experience.
Authors:
B Mayes; R L Brey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  2     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-45     Citation Subset:  -    
Affiliation:
University of Texas Health Science Center at San Antonio, San Antonio, Texas.
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