| Evaluation and treatment of resistant or difficult-to-control hypertension. | |
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MedLine Citation:
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PMID: 19128272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An observational study was conducted in 164 patients with resistant or difficult-to-control hypertension. Treatment was adjusted to achieve blood pressure recommendations from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Patients were mostly male (95.73%) and African American (86.59%) and had an average age of 63.68 years. Comorbidities included diabetes (42.07%) and chronic kidney disease, with an average estimated glomerular filtration rate of 83.55 mL/min/1.73 m(2). At the time of referral, average blood pressure was 160/87 mm Hg. The average number of antihypertensive medications per patient at baseline was 3.43, which increased to 4.06 and 4.18 at 3 and 6 months, respectively (P< or =.0008), with about 80% of patients receiving a diuretic prior to intervention. Blood pressure decreased to 135.55/74.55 and 137.62/74.03 mm Hg at 3 and 6 months, respectively (P<.0001). By month 6, the blood pressure goal was reached in 45.10% of patients. At months 3 and 6, 100% of patients were now receiving a diuretic. The average estimated glomerular filtration rate at month 6 was 79.36 mL/min/1.73 m(2) (P=NS). Patients referred for resistant or difficult-to-control hypertension may be controlled by making targeted adjustments to their medical regimen. |
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Authors:
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David Wojciechowski; Vasilios Papademetriou; Charles Faselis; Ross Fletcher |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 10 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-01-08 Completed Date: 2009-02-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 837-43 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs and Georgetown University Hospital, Washington, DC 20422, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Americans
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statistics & numerical data Antihypertensive Agents / therapeutic use Blood Pressure / drug effects* Comorbidity Diastole / drug effects District of Columbia / epidemiology Drug Resistance Female Glomerular Filtration Rate Humans Hypertension / drug therapy*, ethnology, physiopathology Life Style Male Middle Aged Prevalence Systole / drug effects United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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