Document Detail

Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time.
MedLine Citation:
PMID:  11111235     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). METHODS: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to </=15 s in patients with acquired coagulation deficits. RESULTS: 45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to </=15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). CONCLUSION: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
R G Lerner; J Nelson; E Sorcia; K Grima; R R Kancherla; C M Zarou-Naimo; J C Pehta
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Vox sanguinis     Volume:  79     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-28     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Hematology Section, Department of Medicine, Valhalla, N.Y., USA.
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MeSH Terms
Blood Coagulation Factors / antagonists & inhibitors,  drug effects*
Blood Transfusion*
Detergents / pharmacology*
Double-Blind Method
Hemorrhage / epidemiology,  prevention & control
Hemorrhagic Disorders / blood*,  therapy
Infection Control / methods*
Middle Aged
Plasma / drug effects*
Prothrombin Time*
Solvents / pharmacology*
Virus Diseases / prevention & control*,  transmission
Viruses / drug effects*
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Detergents; 0/Solvents

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