Document Detail

Evaluation of transluminal angioplasty of chronic coronary artery stenosis. Value and limitations assessed in fresh human cadaver hearts.
MedLine Citation:
PMID:  7349945     Owner:  NLM     Status:  MEDLINE    
The possibility of increasing reduced blood flow in atherosclerotic coronary obstruction by catheter balloon dilatation offers a nonsurgical approach to relieve clinical coronary stenosis. To assess the ability of effectively dilating such diseased vessels by transluminal angioplasty, we used the Grüntzig balloon-tipped catheter in 12 fresh human cadaver hearts in which the intervention was performed in 21 noncalcified stenotic areas, including each of the three major coronary arteries. Quantitative coronary arteriography documented decreased obstruction of each lesion; luminal diameter increased 58% (1.9 +/- 0.2 mm to 2.8 +/- 0.3; p less than 0.001) and luminal diameter relative to the most proximal normal coronary segment diminished 61% (46 +/- 4% to 18 +/- 3%; p less than 0.001). Angioplasty was most successfully applied in proximal, discrete, noncalcified lesions of the right and left anterior descending coronaries; calcified, tortuous, middle and distal lesions and the left circumflex coronary were entered with difficulty or unapproachable. Histologic examination revealed microanatomic changes, most often endothelial disruption and atheroma compression, but no serious vascular tears. Dilatation beyond normal coronary diameter caused vessel rupture. This study extends elucidation of the value and limitations of percutaneous transluminal angioplasty in the clinical use of this technique in selected patients for relieving coronary obstruction without surgery.
G Lee; R M Ikeda; J A Joye; H G Bogren; A N DeMaria; D T Mason
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  61     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  AIM; IM    
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MeSH Terms
Arterial Occlusive Diseases / surgery*
Assisted Circulation
Catheterization / instrumentation
Chronic Disease
Coronary Angiography
Coronary Vessels / pathology,  surgery*
Myocardium / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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