Document Detail

Evaluation of transcervical chorionic villus sampling with a completed follow-up of 1550 consecutive pregnancies.
MedLine Citation:
PMID:  2798348     Owner:  NLM     Status:  MEDLINE    
Data from 1,550 consecutive pregnancies after first-trimester prenatal diagnosis by transcervical chorionic villus sampling (TC-CVS) are presented. The sampling efficacy was 97.8 per cent; the mean amount of collected villus tissue was 23 mg (range 5-100 mg). There were 97 affected fetuses, mainly (73.2 per cent) with a chromosomal abnormality or a male karyotype in carriers of X-linked disease. Pregnancy termination in these and four other women for social reasons resulted in 1449 continuing pregnancies. In these pregnancies, the fetal loss rate up to 28 weeks of gestation was 5.1 per cent with the highest loss rate (3.9 per cent) before 16 weeks. When relating this fetal loss rate to maternal age, this was 6.1 per cent in the advanced maternal age group (greater than or equal to 36 years) against 3.1 per cent in the younger age group. In 1,376 pregnancies continuing beyond 28 weeks, the perinatal mortality rate was 1.1 per cent; the percentage of non-genetic congenital anomalies was 0.9 per cent. The reproductive pattern of women at high genetic risk after CVS followed by pregnancy termination was evaluated. Within 12 months after the first CVS followed by pregnancy termination, 70 per cent of women again requested CVS in a subsequent pregnancy.
M G Jahoda; L Pijpers; A Reuss; F J Los; J W Wladimiroff; E S Sachs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  9     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-31     Completed Date:  1989-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  621-8     Citation Subset:  IM; J    
Department of Obstetrics and Gynecology, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Abortion, Induced
Chorionic Villi Sampling* / adverse effects
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Evaluation Studies as Topic
Follow-Up Studies
Gestational Age
Prenatal Diagnosis / methods*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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