Document Detail

Evaluation of the toxic effects of cypermethrin inhalation on the frog heart.
MedLine Citation:
PMID:  14759669     Owner:  NLM     Status:  MEDLINE    
Cypermethrin is widely used as an insecticide on animals and in agriculture, the home, and the garden. The effect of inhaled cypermethrin on the cardiac mechanics, electrophysiology, and ultrastructure in frogs was investigated in this study. Four groups received 100 microL of cypermethrin via inhalation for different exposure times, and one group was used as a control. Electrical and mechanical activities of the heart were recorded, and heart samples were examined at light and transmission electron microscopic levels for all groups. The atrial and ventricular contractile forces on the mechanogram, the amplitude of the P wave and the QRS complex on electrocardiogram, and the heart rate were significantly decreased in cypermethrin-inhalated frogs. The total duration of contraction was prolonged in the study groups. Ultrastructurally, dilatation in smooth endoplasmic reticulum cisterns, a decrease in the number of mitochondria, disorganization in the myofibrils of myocytes, and necrotic changes in endothelial cells were observed. These results suggest that cypermethrin has cardiotoxic effects that increase with exposure time.
Banu Coşkun; Ulkü Cömelekoğlu; Ayşe Polat; F Figen Kaymaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  57     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
Mersin Universitesi Yenişehir Kampusu, Tip Fakultesi, Histoloji Embriyoloji Anabilim Dali, 33169 Mersin, Turkey.
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MeSH Terms
Electrocardiography / veterinary
Heart / drug effects*,  physiology*
Inhalation Exposure*
Insecticides / administration & dosage,  toxicity*
Myocardial Contraction / drug effects
Myocardium / pathology*,  ultrastructure*
Pyrethrins / administration & dosage,  toxicity*
Ranidae / physiology*
Reg. No./Substance:
0/Insecticides; 0/Pyrethrins; 52315-07-8/cypermethrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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