| Evaluation of timolol maleate combination therapy in chronic open-angle glaucoma. | |
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MedLine Citation:
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PMID: 484687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an eight-week study, timolol maleate ophthalmic solution 0.25% was administered twice daily with either pilocarpine 2% four times a day, epinephrine 2% twice a day, carbachol 1.5% four times a day, or 250 mg of acetazolamide twice a day to 44 patients with chronic open-angle glaucoma. Compared to baseline readings on standard therapy alone, mean intraocular pressure was significantly reduced after addition of timolol maleate to each of the regimens. Mean facility of outflow was unaffected. No clinically significant ocular irritation or changes in visual acuity, pupil size, or vital signs were observed in any patient. Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma. |
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Authors:
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E U Keates |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 88 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 565-71 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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administration & dosage Adult Aged Carbachol / administration & dosage Drug Therapy, Combination Epinephrine / administration & dosage Female Glaucoma / drug therapy*, physiopathology Humans Intraocular Pressure Male Middle Aged Pilocarpine / administration & dosage Propanolamines / administration & dosage* Timolol / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Propanolamines; 26839-75-8/Timolol; 51-43-4/Epinephrine; 51-83-2/Carbachol; 59-66-5/Acetazolamide; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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