Document Detail


Evaluation of thyroid nodules with technetium-99m tetrofosmin dual-phase scintigraphy.
MedLine Citation:
PMID:  9211755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Technetium-99m tetrofosmin, a lipophilic cationic complex molecule, was introduced for myocardial imaging. In some biodistribution studies it has also been reported to accumulate in the thyroid gland. Our objectives were to determine which thyroid nodules retain tetrofosmin and whether preoperative evaluation of malignancy is possible. Tetrofosmin scintigraphy was performed in 57 patients with a cold thyroid nodule on previously performed pertechnetate scintigraphy. All patients had undergone ultrasonography and sonographically guided fine-needle aspiration biopsy. The tetrofosmin scintigrams were obtained 5 min (early image) and 1 h (late image) after intravenous injection of 370 MBq. Only nodules that showed clear tracer retention after 1 h in comparison with retention at 5 min were classified as TETRO positive. Nodules without late retention were classified as TETRO negative. All patients underwent surgery and the histological results were compared with the results of tetrofosmin scintigraphy. Ten out of 11 patients with thyroid carcinoma (two pT1, three pT2, five pT4) were TETRO negative. One patient with papillary carcinoma (pT2) was TETRO positive. The mean nodular to thyroid tissue (N/T) ratio for the late scan was 1.0+/-0.20. There were 21 patients with thyroid adenomas (seven follicular, seven microfollicular and seven oxyphilic); 15 of these patients were TETRO positive and six TETRO negative. The mean N/T ratio for the late images was 1.34+/-0.41. All patients with degenerative goitre (24 cases) and the one patient with Hashimoto's disease were TETRO negative after 1 h and the N/T ratio was 0.92+/-0.12 on the late scan. Our results indicate that 99mTc-tetrofosmin scanning is of little value preoperatively in distinguishing thyroid carcinoma from other thyroid nodules. Tetrofosmin tends to demonstrate thyroid adenomas but does not have a routine role in the assessment of thyroid nodules.
Authors:
E Kresnik; H J Gallowitsch; P Mikosch; M Molnar; W Pipam; I Gomez; P Lind
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  24     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-08     Completed Date:  1997-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  716-21     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine and Endocrinology, Landeskrankenhaus Klagenfurt, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Follicular / radionuclide imaging
Adenoma / radionuclide imaging
Carcinoma, Papillary / radionuclide imaging
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Radiopharmaceuticals / diagnostic use*
Sodium Pertechnetate Tc 99m / diagnostic use
Thyroid Neoplasms / radionuclide imaging*
Thyroid Nodule / radionuclide imaging*
Chemical
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 23288-60-0/Sodium Pertechnetate Tc 99m

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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