Document Detail

Evaluation of thyroid dysfunction in patients with paroxysmal atrial fibrillation.
MedLine Citation:
PMID:  17584697     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Atrial fibrillation (AF) is the most frequent cause of hospitalization for arrhythmias. The aim of our study was to evaluate the prevalence of thyroid dysfunction in patients with paroxysmal AF without any cardiomyopathy. METHODS: Two hundred sixty eight patients (164 women and 104 men, mean age 64.9+/-16.9 years) affected by paroxysmal AF entered the present study. Patients underwent routine laboratory examinations with estimation of thyroid hormones levels, standard electrocardiogram (ECG) and transthoracic echocardiography. RESULTS: Thyroid stimulating hormone (TSH) levels were low (<0.3 mU/L) in 168 patients (62.7%) and high (>5 mU/L) in 39 patients (14.9%); 76 patients (28.4%) had high free triiodothyronine (FT3) levels (>4.3 pg/ml) and 91 patients (34.3%) had high free thyroxine (FT4) levels (>1.7 ng/dl); 60 patients (22.4%) had low FT3 levels (<2 pg/ml) and 24 patients (9%) had low FT4 levels (<0.9 ng/dl). Overall, 76.2% of patients with hyperthyroidism were women. Hyperthyroidism was considered subclinical in 68 (40.5%) patients with low SH concentrations. CONCLUSIONS: Thyroid dysfunctions have a high prevalence in AF patients and hyperthyroidism is the most common disorder. Hyperthyroidism in AF patients more often occurs in women than in men. Any minimal but persistent modification of circulating thyroid hormone levels can favor episodes of AF; it can be useful to thoroughly assess thyroid function in all patients suffering from AF.
Pasquale Vergara; Giuseppe Picardi; Gerardo Nigro; Francesco Scafuro; Annabella de Chiara; Raffaele Calabrò; Giuseppe Vergara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology     Volume:  7 Suppl 1     ISSN:  1302-8723     ISO Abbreviation:  Anadolu Kardiyol Derg     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-22     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095069     Medline TA:  Anadolu Kardiyol Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  104-6     Citation Subset:  IM    
Cardiology Department, Second University of Naples, Naples, Italy.
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MeSH Terms
Atrial Fibrillation / complications*,  physiopathology,  ultrasonography
Echocardiography, Transesophageal
Hyperthyroidism / blood,  complications,  epidemiology*
Italy / epidemiology
Middle Aged
Sex Factors
Thyroid Hormones / blood
Reg. No./Substance:
0/Thyroid Hormones

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