Document Detail

Evaluation of thrombocytopenia in the acute coronary syndrome.
MedLine Citation:
PMID:  20703115     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Thrombocytopenia is relatively common in patients with acute coronary syndromes and is associated with an increased risk of adverse outcomes, regardless of the etiology of the low platelet count. Treatment strategies, both medical and mechanical, may cause thrombocytopenia. This review will introduce a differential diagnosis, diagnostic strategies, and treatment options for patients with an acute coronary syndrome.
RECENT FINDINGS: Recent data has strengthened the relationship between thrombocytopenia and adverse outcomes, particularly death and bleeding, in this population of cardiac patients. In addition, bleeding is recognized as a strong independent predictor of an adverse event. Thrombocytopenia may be a marker for acuity of illness and often may be only an association between a low platelet count and therapeutic interventions in this population. Nevertheless, thrombocytopenia due to glycoprotein 2b3a receptor inhibitors, heparins, thienopyridines, and intra-aortic balloon pumps must be recognized and managed appropriately.
SUMMARY: Surveillance for and early recognition of thrombocytopenia, an appropriate differential diagnosis, and early institution of treatment are critically important in the management of patients with acute coronary syndromes.
William H Matthai
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  17     ISSN:  1531-7048     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-12     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Acute Coronary Syndrome / blood,  complications*,  drug therapy
Biological Markers
Fibrinolytic Agents / adverse effects
Heparin / adverse effects
Platelet Aggregation Inhibitors / adverse effects
Thrombocytopenia / chemically induced,  complications*,  diagnosis*
Reg. No./Substance:
0/Biological Markers; 0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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