Document Detail

Evaluation of three sampling methods to monitor outcomes of antiretroviral treatment programmes in low- and middle-income countries.
MedLine Citation:
PMID:  21085709     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Retention of patients on antiretroviral therapy (ART) over time is a proxy for quality of care and an outcome indicator to monitor ART programs. Using existing databases (Antiretroviral in Lower Income Countries of the International Databases to Evaluate AIDS and Médecins Sans Frontières), we evaluated three sampling approaches to simplify the generation of outcome indicators.
METHODS AND FINDINGS: We used individual patient data from 27 ART sites and included 27,201 ART-naive adults (≥15 years) who initiated ART in 2005. For each site, we generated two outcome indicators at 12 months, retention on ART and proportion of patients lost to follow-up (LFU), first using all patient data and then within a smaller group of patients selected using three sampling methods (random, systematic and consecutive sampling). For each method and each site, 500 samples were generated, and the average result was compared with the unsampled value. The 95% sampling distribution (SD) was expressed as the 2.5(th) and 97.5(th) percentile values from the 500 samples. Overall, retention on ART was 76.5% (range 58.9-88.6) and the proportion of patients LFU, 13.5% (range 0.8-31.9). Estimates of retention from sampling (n = 5696) were 76.5% (SD 75.4-77.7) for random, 76.5% (75.3-77.5) for systematic and 76.0% (74.1-78.2) for the consecutive method. Estimates for the proportion of patients LFU were 13.5% (12.6-14.5), 13.5% (12.6-14.3) and 14.0% (12.5-15.5), respectively. With consecutive sampling, 50% of sites had SD within ±5% of the unsampled site value.
CONCLUSIONS: Our results suggest that random, systematic or consecutive sampling methods are feasible for monitoring ART indicators at national level. However, sampling may not produce precise estimates in some sites.
Jean-Michel Tassie; Karen Malateste; Mar Pujades-Rodríguez; Elisabeth Poulet; Diane Bennett; Anthony Harries; Mary Mahy; Mauro Schechter; Yves Souteyrand; François Dabis;
Related Documents :
21277059 - Risk factors affecting postoperative hemorrhage after tooth extraction in patients rece...
21169269 - Outcome of trabeculectomy with mitomycin c in patients with advanced glaucoma.
9664199 - Recognition and management of sinusitis.
21369369 - A randomized, prospective study of the treatment of superficial partial-thickness burns...
21175979 - One year experience of nocturnal home haemodialysis with an alternate night schedule in...
21395649 - Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treat...
19577329 - Scalp necrosis in giant cell arteritis: case report and review of the relevance of this...
17052369 - Predictive factors for recurrent non-toxic goitre in an endemic region.
19686919 - Analysis of 40 cases of intraoral verticosagittal ramus osteotomies to treat dentofacia...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-10
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-04-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e13899     Citation Subset:  IM    
Department of HIV/AIDS, World Health Organisation, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acquired Immunodeficiency Syndrome / drug therapy*,  mortality,  virology
Africa South of the Sahara
Anti-HIV Agents / therapeutic use*
Developing Countries
HIV-1 / drug effects*
Lost to Follow-Up
Outcome Assessment (Health Care) / methods,  statistics & numerical data
Patient Compliance / statistics & numerical data
Patient Dropouts / statistics & numerical data
Program Evaluation / methods*,  statistics & numerical data
Survival Rate
Time Factors
Grant Support
Reg. No./Substance:
0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertrigl...
Next Document:  Optimizing topological cascade resilience based on the structure of terrorist networks.