Document Detail


Evaluation of three rapid tests for diagnosis of P. falciparum and P. vivax malaria in Colombia.
MedLine Citation:
PMID:  17172395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P. falciparum, 279 P. vivax, and 13 mixed P.f/P.v infections and 465 negatives. Paracheck-Pf and NOW-malaria-ICT were more accurate in detecting P. falciparum (sensitivities 90.8% and 90.1%, respectively) in comparison with Optimal-IT (83.6%). NOW showed an acceptable Pf detection rate at low densities (< 500/microL), but resulted in a higher proportion of false positives. For P. vivax diagnosis, Optimal-IT had a higher sensitivity than NOW (91.0% and 81.4%, respectively). The choice between the two Pf/Pv detecting RDTs balances P. falciparum and P. vivax detection rates. Considering some degree of P. falciparum overtreatment and failure to detect all P. vivax cases as more acceptable than missing some cases of P. falciparum, we recommend careful implementation of NOW-malaria-ICT in areas where microscopy is lacking. The price is however still a constraint.
Authors:
Ingrid van den Broek; Olivia Hill; Fabiola Gordillo; Bibiana Angarita; Prudence Hamade; Helen Counihan; Jean-Paul Guthmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  75     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1209-15     Citation Subset:  AIM; IM    
Affiliation:
Médecins sans Frontières (MSF), London, UK. ingrid_vandenbroek@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Child
Child, Preschool
Colombia
Female
Humans
Infant
Malaria, Falciparum / diagnosis*
Malaria, Vivax / diagnosis*
Male
Microscopy / methods
Middle Aged
Plasmodium falciparum / cytology,  isolation & purification
Plasmodium vivax / cytology,  isolation & purification
Quality Control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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