Document Detail


Evaluation of symptomatic drug effects in Alzheimer's disease: strategies for prediction of efficacy in humans.
MedLine Citation:
PMID:  24179995     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In chronic diseases such as Alzheimer's disease (AD), the arsenal of biomarkers available to determine the effectiveness of symptomatic treatment is very limited. Interpretation of the results provided in literature is cumbersome and it becomes difficult to predict their standardization to a larger patient population. Indeed, cognitive assessment alone does not appear to have sufficient predictive value of drug efficacy in early clinical development of AD treatment. In recent years, research has contributed to the emergence of new tools to assess brain activity relying on innovative technologies of imaging and electrophysiology. However, the relevance of the use of these newer markers in treatment response assessment is waiting for validation. This review shows how the early clinical assessment of symptomatic drugs could benefit from the inclusion of suitable pharmacodynamic markers. This review also emphasizes the importance of re-evaluating a step-by-step strategy in drug development.
Authors:
J Deguil; L Ravasi; A Auffret; C Babiloni; D Bartres Faz; V Bragulat; C Cassé-Perrot; V Colavito; M T Herrero Ezquerro; Y Lamberty; L Lanteaume; D Pemberton; F Pifferi; J C Richardson; E Schenker; O Blin; E Tarragon; R Bordet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug discovery today. Technologies     Volume:  10     ISSN:  1740-6749     ISO Abbreviation:  Drug Discov Today Technol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235076     Medline TA:  Drug Discov Today Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e329-42     Citation Subset:  IM    
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