| Evaluation of suspected local recurrence in head and neck cancer: a comparison between PET and PET/CT for biopsy proven lesions. | |
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MedLine Citation:
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PMID: 17223003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: (18)F-FDG PET has a high accuracy for re-staging of head and neck cancer. The purpose of this study was to determine whether the diagnostic accuracy can be further improved with integrated PET/CT. MATERIALS AND METHODS: Forty-nine patients with a mean age of 59+/-18 years were studied retrospectively. Histo-pathological verification was available either from complete tumor resection with or without lymph node dissection (n=27) or direct endoscopic biopsy (n=16) or ultrasound guided biopsy (n=6). Two reviewers blinded to the pathological findings read all PET images in consensus. An experienced radiologist was added for the interpretation of the PET/CT images. RESULTS: Tissue verification was available for 110 lesions in 49 patients. Sixty-seven lesions (61%) were biopsy positive and 43 (39%) were negative for malignant disease. PET and PET/CT showed an overall accuracy for cancer detection of 84 and 88% (p=0.06), respectively. Sensitivity and specificity for PET were 78 and 93% versus 84 (p=NS) and 95% (p=NS) with PET/CT. A patient-by-patient analysis yielded a sensitivity, specificity and accuracy for PET of 80, 56 and 76%, compared to 88% (p=NS), 78% (p=NS) and 86% (p=0.06) for PET/CT. CONCLUSION: The results of this study indicate that PET/CT does not significantly improve the detection of recurrence of head and neck cancer. However, a trend towards improved accuracy was observed (p=0.06). |
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Authors:
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Benjamin S Halpern; Kristen Yeom; Barbara J Fueger; Robert B Lufkin; Johannes Czernin; Martin Allen-Auerbach |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-01-12 |
Journal Detail:
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Title: European journal of radiology Volume: 62 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-16 Completed Date: 2008-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center/Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA 90095-6948, USA. benjamin.halpern@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Female Fluorodeoxyglucose F18 / diagnostic use Head and Neck Neoplasms / diagnosis*, pathology, radiography, radionuclide imaging Humans Image Processing, Computer-Assisted Male Middle Aged Neoplasm Recurrence, Local / diagnosis*, radiography, radionuclide imaging Neoplasm Staging Positron-Emission Tomography* Radiopharmaceuticals / diagnostic use Research Design Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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