| Evaluation of surgical approach for extrahepatic cholangiocarcinoma. | |
| | |
MedLine Citation:
|
PMID: 18086629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The incidence of extrahepatic cholangiocarcinoma increases in recent years. But the diagnosis and treatment are still troublesome to surgeons. This study was designed to explore the value of surgical approach in the treatment of extrahepatic cholangiocarcinoma. METHODS: We retrospectively analyzed the clinical data of 135 patients with extrahepatic cholangiocarcinoma who had been treated in our hospital from January 1992 to December 2006. RESULTS: The ratio of extrahepatic cholangiocarcinoma to biliary duct diseases was 1.81%. The rates of total resection and radical resection were 70.75% (75/106) and 56.60% (60/106), respectively. The overall 1-, 3-, 5-year survival rates were 46.93%, 37.33% and 18.75%, respectively. The 1-, 3-, 5-year survival rates were better in the radical resection group (74.94%, 55.74% and 41.27%, respectively) than in the palliative resection group (42.86%, 26.79% and 26.79%, respectively) (P<0.05). The survival rates of patients who had undergone palliative resection were higher than those of patients who had been subjected to palliative drainage or non-operation: 1-, 3-, 5-year survival rates were 42.86%, 26.79%, 26.79% vs. 23.33%, 6.67%, 0 or 17.86%, 0, 0 (P<0.05). While the survival rates were not significantly different between palliative drainage and non-operation (P<0.05). Multivariate analysis revealed that the histopathological grades, TNM stages and modalities were key factors influencing the outcome. CONCLUSIONS: The outcome of the patients with extrahepatic cholangiocarcinoma is still not optimistic. Radical resection is the first choice for the treatment of tumors. |
| | |
Authors:
|
Qian-Feng Shi; Ting-Bo Liang; Yun-Sheng Qin; Wei-Lin Wang; Yan Shen; Min Zhang; Shu-Sen Zheng |
Related Documents
:
|
21188109 - Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma. 17409979 - Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency... 2924669 - Extended resection for locally advanced primary adenocarcinoma of the rectum. 19700339 - The impact of the type of resection on survival in patients with n1 non-small-cell lung... 9440759 - Phase ii trial of preoperative radiation therapy and chemotherapy for patients with loc... 18520589 - Squamous cell carcinoma of the temporal bone: results and management. 21398049 - Low-dose radiotherapy in indolent lymphoma. 22497669 - Ultrasonographic assessment of abdominal lymph nodes in puppies. 20672319 - L1, β-catenin, and e-cadherin expression in patients with colorectal cancer: correlati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hepatobiliary & pancreatic diseases international : HBPD INT Volume: 6 ISSN: 1499-3872 ISO Abbreviation: HBPD INT Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-12-18 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101151457 Medline TA: Hepatobiliary Pancreat Dis Int Country: China |
Other Details:
|
Languages: eng Pagination: 622-6 Citation Subset: IM |
Affiliation:
|
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Bile Duct Neoplasms / mortality, pathology, surgery* Bile Ducts, Extrahepatic* Cholangiocarcinoma / mortality, pathology, surgery* Female Humans Male Middle Aged Neoplasm Staging Retrospective Studies Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dynamic expression of rat heat shock protein gp96 and its gene during development of hepatocellular ...
Next Document: Possible relationship between cholecystectomy and subsequent occurrence of primary common bile duct ...