| Evaluation of sudomotor function in diabetes using the dynamic sweat test. | |
| | |
MedLine Citation:
|
PMID: 20038772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The study of sudomotor function represents a useful tool to evaluate autonomic disorders. Currently available tests allow either the measurement of sweat output from the whole body or selected small skin locations over time, or quantification of the number and size of sweat drops at a fixed time after stimulation. We devised a dynamic sweat test (DST) that measures at the same time sweat gland density, distribution of active glands, and sweat rate, and applied it to the evaluation of sudomotor function in diabetes. METHODS: The DST was used to evaluate sweating in the forearm of 14 asymptomatic diabetic subjects and 14 age- and sex-matched healthy controls. Distal leg was also tested in 7 patients and 7 controls. The formation of the imprint of pilocarpine-induced sweating was recorded by a digital video camera through a cornstarch-powdered transparent tape used as a contrast-enhancing device. Mean sweat output per gland and per skin area and sweat gland density per cm(2) were evaluated. RESULTS: We observed a significant reduction of sweating in diabetic subjects as compared to controls; sweat gland density per cm(2) (59.7 +/- 18.6 vs 83.7 +/- 17.3; p < 0.05) and mean sweat output (nL/min) per gland (4.7 +/- 0.7 vs 8.3 +/- 2.7; p = 0.01) and per skin area (261 +/- 100 vs 645 +/- 296; p = 0.01) were reduced in the lower limb. Values for the forearm were not significantly different from controls. CONCLUSIONS: Dynamic sweat test is an easy-to-perform, informative method to study sudomotor function. It provides the ability to detect subtle functional changes occurring in the early stages of diabetic neuropathy. |
| | |
Authors:
|
V Provitera; M Nolano; G Caporaso; A Stancanelli; L Santoro; W R Kennedy |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 74 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-29 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 50-6 Citation Subset: AIM; IM |
Affiliation:
|
Neurology Department, "S. Maugeri" Foundation I.R.C.C.S., Via Bagni Vecchi, 1, 82037 Telese Terme (BN), Italy. vincenzo.provitera@fsm.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Autonomic Nervous System Diseases / etiology* Body Temperature / physiology Diabetes Mellitus / diagnosis, physiopathology* Female Humans Male Middle Aged Retrospective Studies Sweat Glands / pathology* Sweating / physiology* Sympathetic Nervous System / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The interplay between the immune and central nervous systems in neuronal injury.
Next Document: Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients.