| Evaluation of substrates for 90 degrees peel adhesion--a collaborative study. II. Transdermal drug delivery systems. | |
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MedLine Citation:
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PMID: 18546200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high-density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot, Climara, Catapres-TTS, Duragesic, and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of approximately 3 min, a peel angle of 90 degrees, and a peel speed of 300 mm/min. Differences among TDDSs were greater for SS than for HDPE, using the F statistic for testing for differences among TDDSs means as a measure of heterogeneity, thereby indicating greater discrimination by SS. |
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Authors:
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Anna M Wokovich; Stanley A Brown; Meiyu Shen; William H Doub; Bing Cai; Nakissa Sadrieh; Mei Ling Chen; Stella Machado; Lucinda F Buhse |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical materials research. Part B, Applied biomaterials Volume: 88 ISSN: 1552-4981 ISO Abbreviation: J. Biomed. Mater. Res. Part B Appl. Biomater. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-05-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234238 Medline TA: J Biomed Mater Res B Appl Biomater Country: United States |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley Periodicals, Inc. |
Affiliation:
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Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, Missouri, USA. anna.wokovich@fda.hhs.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adhesiveness Administration, Cutaneous* Biocompatible Materials / chemistry* Cadaver Cell Adhesion Clonidine / administration & dosage Drug Delivery Systems* Estradiol / administration & dosage Fentanyl / administration & dosage Humans Materials Testing / methods* Polyethylene / chemistry Quality Control Skin / drug effects* Surgical Tape* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 4205-90-7/Clonidine; 437-38-7/Fentanyl; 50-28-2/Estradiol; 9002-88-4/Polyethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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