| Evaluation of subclinical cerebral injury and neuropsychologic function in patients undergoing carotid endarterectomy. | |
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MedLine Citation:
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PMID: 18504102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined subclinical alterations of cerebral function during carotid endarterectomy (CEA) and predictability of minor cerebral damage by perioperative levels of biochemical markers of brain damage (S100B and neuron-specific enolase [NSE]). Twenty consecutive patients with > or =70% asymptomatic carotid stenosis undergoing elective CEA were enrolled. Pre- and postoperative testing included magnetic resonance imaging (MRI) of the head, a standardized neurological exam, a battery of neuropsychological tests, and measurement of serum levels of S100B and NSE. There were no major ischemic strokes. In one patient, a mild weakness of the contralateral lower extremity was discovered on neurological examination; in another individual, postoperative MRI revealed two new small subcortical lesions without clinical correlate. While S100B increased significantly early after opening of the carotid clamp (p = 0.015), the NSE increase did not reach statistical significance. As a group, participants obtained a significantly higher mean overall neuropsychological score at follow-up testing (p < 0.05). In one patient, a significant decline of cognitive function was observed. This was the only individual to obtain a consistently high S100B and NSE increase. Neuropsychological testing combined with measurements of S100B and NSE may improve sensitivity when assessing subtle cerebral damage following CEA. |
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Authors:
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Juergen Falkensammer; W Andrew Oldenburg; Andrea J Hendrzak; Beate Neuhauser; Otto Pedraza; Tanis Ferman; Joseph Klocker; Matthias Biebl; Beate Hugl; James F Meschia; Albert G Hakaim; Thomas G Brott |
Publication Detail:
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Type: Journal Article Date: 2008-05-27 |
Journal Detail:
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Title: Annals of vascular surgery Volume: 22 ISSN: 1615-5947 ISO Abbreviation: Ann Vasc Surg Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-14 Completed Date: 2008-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 497-504 Citation Subset: IM |
Affiliation:
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Section of Vascular Surgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Brain Damage, Chronic / diagnosis, etiology* Carotid Stenosis / surgery Cognition Disorders / diagnosis*, etiology Electroencephalography Endarterectomy, Carotid / adverse effects* Female Humans Male Middle Aged Neurologic Examination Neuropsychological Tests* Phosphopyruvate Hydratase / blood S100 Proteins / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/S100 Proteins; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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