Document Detail

Evaluation of the stimulant content of dietary supplements marketed as "ephedra-free".
MedLine Citation:
PMID:  17594988     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: With the removal of stimulant herb ephedra from the market, dietary supplement manufacturers are coming out with many ephedra-free products. Some of these products appear to simply replace ephedra with stimulants by another name. OBJECTIVE: To determine the stimulant content of dietary supplements marketed as ephedra-free. DESIGN: Survey of the ingredients of dietary supplements that are stated as "ephedra-free" in the label or promotional material. RESULTS: Out of 36 products marketed as ephedra-free, 32 (89%) contained a methylxanthine such as caffeine or theobromine, 21 (58%) contained the stimulant synephrine, and 20 (56%) contained both a methylxanthine and synephrine. LIMITATIONS: The results of this evaluation pertain only to products discovered through Internet and database searching. CONCLUSIONS: Most dietary supplement makers have substituted stimulants by a different name for ephedra in their "ephedra-free" products. Patients need to be advised that ephedra-free products are not necessarily stimulant free and may present a significant risk.
Philip J Gregory
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of herbal pharmacotherapy     Volume:  7     ISSN:  1522-8940     ISO Abbreviation:  J Herb Pharmacother     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-27     Completed Date:  2007-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888586     Medline TA:  J Herb Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Thomas J. Long School of Pharmacy & Health Professions, Omaha, NE, USA.
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MeSH Terms
Alkaloids / analysis
Anti-Obesity Agents / analysis*
Caffeine / analysis
Central Nervous System Stimulants / analysis
Dietary Supplements / analysis*
Drug Labeling / standards
Drug and Narcotic Control
Drugs, Chinese Herbal / analysis*
Ephedrine / analysis
Mass Spectrometry
Metals, Heavy / analysis
Phytotherapy / standards*
Plant Preparations / chemistry
Reg. No./Substance:
0/Alkaloids; 0/Anti-Obesity Agents; 0/Central Nervous System Stimulants; 0/Drugs, Chinese Herbal; 0/Metals, Heavy; 0/Plant Preparations; 299-42-3/Ephedrine; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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