| Evaluation of stannous oxidation in the preparation of ultrahigh-purity 99m Tc(V)-DMSA. | |
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MedLine Citation:
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PMID: 11606894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been shown previously that renal kit, trivalent technetium-99m dimercaptosuccinic acid [99mTc(III)-DMSA], can be transformed into tumour imaging agent, pentavalent technetium-99m DMSA [99mTc(V)-DMSA], by adding sodium bicarbonate (NaHCO3) and subsequently bubbling with oxygen. However, the purity of this pentavalent preparation was reported to be in the range 83-94% at best. In this study, the preparation of ultrahigh-purity 99mTc(V)-DMSA is described, and the role of stannous oxidation in the conversion of 99mTc(III)-DMSA to 99mTc(V)-DMSA is evaluated in order to understand the underlying mechanism. The results show that controlled oxygen bubbling increases the 99mTc(V)-DMSA levels, with a concomitant decrease in the 99mTc(III)-DMSA levels, in a time-dependent pattern. The purity of the pentavalent DMSA is shown to be consistently very high (>99%), as estimated by chromatography, and this correlates very well with the minimal or no renal uptake of this compound in patient studies. |
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Authors:
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V Kumar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 22 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-18 Completed Date: 2002-01-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 1261-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia. nvk@imag.wsahs.nsw.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Stability Humans Kinetics Neoplasms / radionuclide imaging Oxidation-Reduction Radiopharmaceuticals / chemistry, diagnostic use, pharmacokinetics Reagent Kits, Diagnostic Sodium Bicarbonate Technetium Tc 99m Dimercaptosuccinic Acid / chemistry*, diagnostic use, pharmacokinetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Reagent Kits, Diagnostic; 144-55-8/Sodium Bicarbonate; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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