Document Detail

Evaluation of stannous oxidation in the preparation of ultrahigh-purity 99m Tc(V)-DMSA.
MedLine Citation:
PMID:  11606894     Owner:  NLM     Status:  MEDLINE    
It has been shown previously that renal kit, trivalent technetium-99m dimercaptosuccinic acid [99mTc(III)-DMSA], can be transformed into tumour imaging agent, pentavalent technetium-99m DMSA [99mTc(V)-DMSA], by adding sodium bicarbonate (NaHCO3) and subsequently bubbling with oxygen. However, the purity of this pentavalent preparation was reported to be in the range 83-94% at best. In this study, the preparation of ultrahigh-purity 99mTc(V)-DMSA is described, and the role of stannous oxidation in the conversion of 99mTc(III)-DMSA to 99mTc(V)-DMSA is evaluated in order to understand the underlying mechanism. The results show that controlled oxygen bubbling increases the 99mTc(V)-DMSA levels, with a concomitant decrease in the 99mTc(III)-DMSA levels, in a time-dependent pattern. The purity of the pentavalent DMSA is shown to be consistently very high (>99%), as estimated by chromatography, and this correlates very well with the minimal or no renal uptake of this compound in patient studies.
V Kumar
Related Documents :
24577824 - Eicosapentaenoic acid in serum lipids could be inversely correlated with severity of cl...
16307434 - Biodegradable hyaluronic acid/n-carboxyethyl chitosan/protein ternary complexes as impl...
15271524 - The kinetics and mechanisms of reactions of iron(iii) with caffeic acid, chlorogenic ac...
23787314 - The variation of volatile fatty acid compositions in sewer length, and its effect on th...
18800194 - Correlation between organic acid exudation and metal uptake by ectomycorrhizal fungi gr...
6715524 - Disk diffusion susceptibility testing of ticarcillin plus clavulanic acid.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  22     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-18     Completed Date:  2002-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1261-6     Citation Subset:  IM    
Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Stability
Neoplasms / radionuclide imaging
Radiopharmaceuticals / chemistry,  diagnostic use,  pharmacokinetics
Reagent Kits, Diagnostic
Sodium Bicarbonate
Technetium Tc 99m Dimercaptosuccinic Acid / chemistry*,  diagnostic use,  pharmacokinetics
Tissue Distribution
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Reagent Kits, Diagnostic; 144-55-8/Sodium Bicarbonate; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Is deconvolution applicable to renography?
Next Document:  A collimator with a magnetic personality?