Document Detail


Evaluation of stannous oxidation in the preparation of ultrahigh-purity 99m Tc(V)-DMSA.
MedLine Citation:
PMID:  11606894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been shown previously that renal kit, trivalent technetium-99m dimercaptosuccinic acid [99mTc(III)-DMSA], can be transformed into tumour imaging agent, pentavalent technetium-99m DMSA [99mTc(V)-DMSA], by adding sodium bicarbonate (NaHCO3) and subsequently bubbling with oxygen. However, the purity of this pentavalent preparation was reported to be in the range 83-94% at best. In this study, the preparation of ultrahigh-purity 99mTc(V)-DMSA is described, and the role of stannous oxidation in the conversion of 99mTc(III)-DMSA to 99mTc(V)-DMSA is evaluated in order to understand the underlying mechanism. The results show that controlled oxygen bubbling increases the 99mTc(V)-DMSA levels, with a concomitant decrease in the 99mTc(III)-DMSA levels, in a time-dependent pattern. The purity of the pentavalent DMSA is shown to be consistently very high (>99%), as estimated by chromatography, and this correlates very well with the minimal or no renal uptake of this compound in patient studies.
Authors:
V Kumar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  22     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-18     Completed Date:  2002-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1261-6     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia. nvk@imag.wsahs.nsw.gov.au
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MeSH Terms
Descriptor/Qualifier:
Drug Stability
Humans
Kinetics
Neoplasms / radionuclide imaging
Oxidation-Reduction
Radiopharmaceuticals / chemistry,  diagnostic use,  pharmacokinetics
Reagent Kits, Diagnostic
Sodium Bicarbonate
Technetium Tc 99m Dimercaptosuccinic Acid / chemistry*,  diagnostic use,  pharmacokinetics
Tissue Distribution
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Reagent Kits, Diagnostic; 144-55-8/Sodium Bicarbonate; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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