Document Detail


Evaluation of the skin sensitizing potency of chemicals by using the existing methods and considerations of relevance for elicitation.
MedLine Citation:
PMID:  15701129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Technical Committee of Classification and Labelling dealing with harmonized classification of substances and classification criteria under Directive 67/548/EEC on behalf of the European Commission nominated an expert group on skin sensitization in order to investigate further the possibility for potency consideration of skin sensitizers for future development of the classification criteria. All substances and preparations should be classified on the basis of their intrinsic properties and should be labelled accordingly with the rules set up in the Directive 67/548/EEC. The classification should be the same under their full life cycle and in the case that there is no harmonized classification the substance or preparation should be self-classified by the manufacturer in accordance with the same criteria. The Directive does not apply to certain preparations in the finished state, such as medical products, cosmetics, food and feeding stuffs, which are subject to specific community legislation. The main questions that are answered in this report are whether it would be possible to give detailed guidance on how to grade allergen potency based on the existing methods, whether such grading could be translated into practical thresholds and whether these could be set for both induction and elicitation. Examples are given for substances falling into various potency groups for skin sensitization relating to results from the local lymph node assay, the guinea pig maximization test, the Buehler method and human experience.
Authors:
David A Basketter; Klaus E Andersen; Carola Liden; Henk Van Loveren; Anders Boman; Ian Kimber; Kristiina Alanko; Elisabet Berggren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  52     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-09     Completed Date:  2005-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Affiliation:
Applied Science and Technology, Safety and Environmental Assurance Centre, Unilever Colworth Laboratory, Sharnbrook, Bedford MK44 1LQ, UK. david.basketter@unilever.com
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MeSH Terms
Descriptor/Qualifier:
Advisory Committees
Allergens / administration & dosage*,  classification*
Animals
Dermatitis, Allergic Contact / diagnosis*,  etiology*
Dose-Response Relationship, Drug
Dose-Response Relationship, Immunologic
European Union
Humans
International Cooperation
Patch Tests / methods,  standards*
Reference Standards
Chemical
Reg. No./Substance:
0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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