| Evaluation of skin irritation and contact sensitizing potential of fenticonazole. | |
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MedLine Citation:
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PMID: 2346545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double blind, randomized clinical trial was performed on twelve healthy volunteers to evaluate the irritation potential of fenticonazole 2% cream (Lomexin) and spray versus micomazole 2% cream and econazole 1% spray. The contact-sensitizing potential of the two fenticonazole preparations was also investigated. There was no evidence of irritation after the treatments with fenticonazole cream, its excipients, miconazole cream and fenticonazole spray excipients, whereas signs of irritation were observed in four cases after treatment with the spray formulations (two after fenticonazole, two after econazole). The contact-sensitizing test was performed only with fenticonazole 2% cream and spray. Neither spray nor cream formulation of fenticonazole showed evidence of sensitization in any of the twelve subjects. |
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Authors:
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P Pigatto; E Colli; M Scatigna; A Finzi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 40 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-07-03 Completed Date: 1990-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 329-31 Citation Subset: IM |
Affiliation:
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2nd Department of Dermatology, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dermatitis, Contact / etiology* Drug Evaluation Econazole / adverse effects Female Humans Imidazoles / adverse effects* Irritants Male Miconazole / adverse effects Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Irritants; 22916-47-8/Miconazole; 27220-47-9/Econazole; 72479-26-6/fenticonazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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