| Evaluation of six tumor markers in patients with carcinoma of unknown primary. | |
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MedLine Citation:
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PMID: 7505876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have retrospectively evaluated six serum tumor markers in 85 patients with carcinoma of unknown primary. The serum levels of carcinoembryonic antigen (CEA), CA 19-9, CA 15-3, CA 125, beta-chorionic gonadotropin (beta-HCG) and alpha-fetoprotein (AFP) were related with the histological pattern (undifferentiated carcinoma or adenocarcinoma), the number and the site of metastases, as well as the response to chemotherapy and the patients' survival. More than 40% of the patients had increased serum levels of all six tumor markers, except of AFP which was found to be increased in only 17% of them. Increased levels of CA 19-9 were related to metastatic adenocarcinoma, whereas CA 19-9 and CA 15-3 had a relationship with more advanced disease. Patients with liver involvement had higher mean levels of CEA and CA 19-9 as compared to those with nodal disease. None of these markers was found to have a predictive value for response to chemotherapy or survival. Although the present study has a retrospective nature, it allows us to conclude that patients with CUP have a nonspecific over-expression of the above serum tumor markers and that routine use of these markers does not offer any diagnostic or prognostic assistance. |
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Authors:
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N Pavlidis; J Kalef-Ezra; E Briassoulis; D Skarlos; P Kosmidis; K Saferiadis; E Bairaktari; D Bafaloukos; A Maravegias; D Theoharis |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Medical and pediatric oncology Volume: 22 ISSN: 0098-1532 ISO Abbreviation: Med. Pediatr. Oncol. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-02-03 Completed Date: 1994-02-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7506654 Medline TA: Med Pediatr Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Ioannina, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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secondary Adult Antigens, Neoplasm / blood* Antigens, Tumor-Associated, Carbohydrate / blood Bone Neoplasms / secondary Carcinoembryonic Antigen / blood Carcinoma / secondary Central Nervous System Neoplasms / secondary Chorionic Gonadotropin / blood Female Humans Linear Models Liver Neoplasms / secondary Lung Neoplasms / secondary Lymph Nodes Male Middle Aged Neoplasms, Unknown Primary / blood*, drug therapy, mortality Peritoneal Neoplasms / secondary Predictive Value of Tests Retrospective Studies Survival Rate Tumor Markers, Biological / blood* alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Carcinoembryonic Antigen; 0/Chorionic Gonadotropin; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins |
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