Document Detail

Evaluation of single sample clearance calculations in 902 patients. A comparison of multiple and single sample techniques.
MedLine Citation:
PMID:  9059404     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To derive new formulae for the calculation of single sample clearance of the contrast medium iohexol and to compare the formulae to a selection of existing single sample clearance formulae derived for the calculation of 51Cr-EDTA and 99mTc-DTPA clearance. MATERIAL AND METHODS: Glomerular filtration rate (GFR) was calculated from total plasma clearance of iohexol used for urography in 902 patients. Two plasma samples were drawn in each patient. Automated x-ray fluorescence analysis equipment was used for the plasma iodine analysis. Single and multiple sample iohexol clearance values were compared. In 77 patients the multiple sample clearance values were additionally compared to a 51Cr-EDTA clearance performed simultaneously or within 14 days. RESULTS: The precision of the results calculated by the existing single sample clearance formulae and the derived iohexol single sample clearance formulae were essentially the same. The most precise of the derived formulae was that based on the Bak Christensen & Groth formula. The correlation between multiple sample clearance of iohexol and 51Cr-EDTA was high (r = 0.918). CONCLUSION: Iohexol can substitute 51Cr-EDTA for GFR measurement. A valid GFR can be calculated from a single plasma sample determination of iohexol clearance using either the existing formulae or the new formulae derived from the present study.
S Lundqvist; S O Hietala; S Groth; J G Sjödin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  38     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
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MeSH Terms
Aged, 80 and over
Chromium Radioisotopes / administration & dosage,  diagnostic use,  pharmacokinetics*
Contrast Media / administration & dosage,  pharmacokinetics*
Edetic Acid / administration & dosage,  diagnostic use,  pharmacokinetics*
Glomerular Filtration Rate
Injections, Intravenous
Iohexol / administration & dosage,  diagnostic use,  pharmacokinetics*
Metabolic Clearance Rate
Middle Aged
Scintillation Counting / statistics & numerical data
Spectrometry, X-Ray Emission / statistics & numerical data
Time Factors
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Contrast Media; 60-00-4/Edetic Acid; 66108-95-0/Iohexol

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