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Evaluation of the shear force of single cancer cells by vertically aligned carbon nanotubes suitable for metastasis diagnosis.
MedLine Citation:
PMID:  23340873     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Vertically aligned carbon nanotube (VACNT) arrays have been demonstrated as probes for rapid quantifying of cancer cell deformability with high resolution. Through entrapment of various cancer cells on CNT arrays, the deflections of the nanotubes during cell deformation were used to derive the lateral cell shear force using a large deflection mode method. It is observed that VACNT beams act as sensitive and flexible agents, which transfer the shear force of cells trapped on them by an observable deflection. The metastatic cancer cells have significant deformable structures leading to a further cell traction force (CTF) than primary cancerous one on CNT arrays. The elasticity of different cells could be compared by their CTF measurement on CNT arrays. This study presents a nanotube-based methodology for quantifying the single cell mechanical behavior, which could be useful for understanding the metastatic behavior of cells.
Authors:
M Abdolahad; S Mohajerzadeh; M Janmaleki; H Taghinejad; M Taghinejad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Integrative biology : quantitative biosciences from nano to macro     Volume:  -     ISSN:  1757-9708     ISO Abbreviation:  Integr Biol (Camb)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101478378     Medline TA:  Integr Biol (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Nano-Electronic Center of Excellence, Nano-Electronics and Thin Film Lab., School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran. mohajer@ut.ac.ir.
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