Document Detail


Evaluation of serum uric acid levels in normal pregnant Nigerian women.
MedLine Citation:
PMID:  19562928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypertensive disorders in pregnancy are common in our environment. The aetiology is unknown and the prognostic indicators of the severity of maternal and fetal complications are variable. The level of uric acid, which is one of the prognostic indicators, is altered in normal pregnancy and as pregnancy advances. Base line values are thus extremely important to enable reasonable prognostic assessment in hypertensive pregnancies. OBJECTIVES: To determine levels of serum uric acid during normal pregnancy in University of Nigeria Teaching Hospital (UNTH) Enugu. STUDY DESIGN: settings and methods: Sixty- five pregnant and 65 non-pregnant women with age range 20-38 years were recruited. The pregnant women were in their second and third trimesters, attending antenatal clinic at the University of Nigeria Teaching Hospital Enugu. Serum levels of uric acid were determined for the entire subjects. RESULTS: The serum uric acid levels were significantly lower in the pregnant women than in controls (P < 0.001). 0.15 +/- 0.03 mmol/L in the second trimester, 0.14 +/- 0.02 mmol/L in the third trimester and 0.29 +/- 0.04 mmoL for control. CONCLUSION: The low levels in pregnancy and as pregnancy progresses should be taken into consideration when monitoring hypertensive disorders in pregnancy using serum uric acid. Thus levels that are within normal for non pregnant population may indeed be an indication for intervention in pregnancies complicated by preeclampsia.
Authors:
U I Nwagha; F E Ejezie; E E Iyare
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nigerian journal of clinical practice     Volume:  12     ISSN:  1119-3077     ISO Abbreviation:  Niger J Clin Pract     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-08-20     Revised Date:  2009-09-22    
Medline Journal Info:
Nlm Unique ID:  101150032     Medline TA:  Niger J Clin Pract     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
Department of Physiology/Obstetrics and Gynaecology, College of Medicine, University of Nigeria, Enugu Campus. uchenwagha@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Nigeria
Pregnancy / blood*
Reference Values
Uric Acid / blood*
Young Adult
Chemical
Reg. No./Substance:
69-93-2/Uric Acid
Comments/Corrections
Erratum In:
Niger J Clin Pract. 2009 Jun;12(2):228

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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