| Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age. | |
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MedLine Citation:
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PMID: 18377683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective was to study the evaluation of serum transferrin receptor (sTfR) for Fe deficiency in women of child-bearing age. Primary screening was performed in 942 women ranging in child-bearing age. Serum ferritin (SF), Zn protoporphyrin (ZPP) and Hb were determined. Then the subjects were divided into four groups: normal, Fe store depletion (IDs), Fe-deficiency erythropoiesis and Fe-deficiency anaemia. sTfR was determined and sTfR/SF (sTfR/logSF and log(sTfR/SF)) was calculated. Changes of sTfR in women of different Fe status were observed. A receiver-operating characteristic (ROC) curve was used to evaluate whether sTfR had proper diagnostic efficacy for functional Fe deficiency. The levels of sTfR increased significantly along with the aggravation of Fe deficiency. Increase of STfR/SF along with the aggravation of Fe deficiency was more significant than that of sTfR. STfR had a significant negative correlation with SF and Hb, while it had a significant positive correlation with ZPP. The ROC curve showed that the diagnostic effective rate of sTfR for Fe deficiency could reach 83 %. At this point, the sensitivity was 79 % and the specificity was 63 %. Log(sTfR/SF) could be considered to have the highest effective ratio in detecting IDs, since it reached 99 %. STfR and sTfR/SF could both reflect body Fe-deficiency status specifically. They could be used as reliable indicators for evaluating Fe status and diagnosing Fe deficiency in women of child-bearing age. |
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Authors:
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Xiao-Ming Lin; Juan Zhang; Zhi-Yong Zou; Zhu Long; Wei Tian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-01 |
Journal Detail:
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Title: The British journal of nutrition Volume: 100 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-07 Completed Date: 2008-11-18 Revised Date: 2009-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1104-8 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100083 China. xmlin1978@bjmu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Iron-Deficiency / blood, diagnosis* Biological Markers / blood Female Ferritins / blood Health Status Hemoglobins / analysis Humans Protoporphyrins / blood ROC Curve Receptors, Transferrin / blood* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins; 0/Protoporphyrins; 0/Receptors, Transferrin; 15442-64-5/zinc protoporphyrin; 9007-73-2/Ferritins |
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