Document Detail

Evaluation of serum levels of interleukin-10, interleukin-11 and leukemia inhibitory factor in differentiation of eutopic and tubal ectopic pregnancies.
MedLine Citation:
PMID:  21077528     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF STUDY: To investigate whether serum levels of leukemia inhibitory factor (LIF), interleukin 10 (IL-10) and interleukin 11 (IL-11) are different in reference to the site of implantation.
METHODS: Seventeen patients with laparoscopic diagnoses of tubal ectopic pregnancy (EP) and 19 patients with intrauterine pregnancy delivering healthy term neonates (IUP) were prospectively evaluated for LIF, IL-10 and IL-11 levels. The data were compared by using the Student's t-test, chi-square test, Kruskal-Wallis and the Mann-Whitney U test with Bonferroni's correction (p < 0.05) as appropriate.
RESULTS: A statistically significant difference was observed in serum LIF levels between the EP and IUP groups (p = 0.002). Ranges of LIF were 15-300 and 70-1200 ng/ml for the IUP and EP groups, respectively. There were no significant differences between groups in terms of IL-10 and IL-11 levels.
CONCLUSION: LIF, but not IL-10 or IL-11, levels may be increased in early tubal ectopic pregnancies when compared to normal intrauterine pregnancies.
A C Iyibozkurt; I Kalelioğlu; S Gursoy; A Corbacioglu; N Gurelpolat; G E Karahan; H Saygili; E Bengisu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  37     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-16     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Division of Virology and Basic Immunology, Istanbul University, Istanbul Faculty of Medicine, Capa, Istanbul, Turkey.
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MeSH Terms
Biological Markers / blood
Interleukin-10 / blood*
Interleukin-11 / blood*
Leukemia Inhibitory Factor / blood*
Pregnancy / blood*
Pregnancy, Ectopic / blood*
Prospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-11; 0/Leukemia Inhibitory Factor; 130068-27-8/Interleukin-10

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