Document Detail

Evaluation of serum leptin levels during normal pregnancy and in pre-eclampsia.
MedLine Citation:
PMID:  19999227     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study was designed to compare the serum leptin levels in normal pregnancies with those pregnancies which are complicated by pre-eclampsia and to investigate the possibility of leptin being a marker of severity of pre-eclampsia. METHODS: This was a comparative cross-sectional study, conducted at the Department of Gynaecology and Obstetric, Jinnah Postgraduate Medical Centre (JPMC), Karachi. For this purpose 45 primigravidas with normal pregnancy and 45 primigravidas with pre-eclamptic pregnancy were selected who were in their third trimester All the subjects were of the same maternal age, gestational age, height and weight. Serum leptin levels were determined by immunoenzymometric assay. RESULTS: The study included 90 patients, divided into two groups. The serum leptin levels were found to be elevated in pre-eclamptic group as compared to normal pregnancy. When comparison was made on the basis of severity of pre-eclampsia, the serum leptin levels were found to be increased in severe group as compared to mild group. CONCLUSION: From this study it was concluded that the levels of serum leptin were higher in pre-eclamptic group when compared to controls during the third trimester of pregnancy indicating the possible role of leptin in the pathogenesis of pre-eclampsia. Also the elevated level of leptin may help in the prediction of the disease and may serve as a marker of severity of pre-eclampsia.
Uzma Iftikhar; Akbar Khoja; Mehjabeen; Azhar Iqbal; Khemomal A Karira
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  20     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2009-12-11     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
Department of Physiology, Hamdard College of Medicine & Dentistry, Hamdard University, Karachi, Pakistan.
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MeSH Terms
Biological Markers / blood
Cross-Sectional Studies
Leptin / blood*
Pre-Eclampsia / blood*,  diagnosis
Severity of Illness Index
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Leptin

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