Document Detail


Evaluation of serum granulocyte colony stimulating factor levels in infants of preeclamptic mothers.
MedLine Citation:
PMID:  17479645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we aimed to evaluate the relationship between serum granulocyte colony stimulating factor (G-CSF) levels and absolute neutrophil counts (ANC) in infants of preeclamptic mothers. The study group consisted of 31 infants of preeclamptic mothers while the control group consisted of 24 gestational age-adjusted infants of normotensive mothers. G-CSF levels were determined by enzyme-linked immunosorbent assay (ELISA). The mean G-CSF level was 981.8 +/- 1682.5 (25.7-5924) pg/ml in the study group and 770.8 +/- 1779 (18-8526) pg/ml in control group (p > 0.05). There was no correlation between G-CSF levels and absolute or total neutrophil counts on the 1st, 2nd and 7th days in infants of preeclamptic mothers. There were positive correlations between G-CSF levels and ANC on the 1st and 7th days of life in infants of normotensive mothers. Neutropenia developed in 42.3% of the study group and in 21.7% of the control group on the 1st day of life (p > 0.05). On the 2nd day, neutropenia was observed in 61.5% of the study group and 26.1% of the control group (p = 0.013). Serum G-CSF levels were not low in neutropenic babies of preeclamptic mothers. In contrast, higher G-CSF levels in neutropenic infants suggest impaired G-CSF response in infants of preeclamptic mothers.
Authors:
Sükrü Güner; Sule Yiğit; Mualla Cetin; Serafettin Kirazli; Murat Yurdakök; Ayşe Korkmaz; Gülsevin Tekinalp
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  49     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2007 Jan-Mar
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Başkent University, Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Enzyme-Linked Immunosorbent Assay
Female
Granulocyte Colony-Stimulating Factor / blood*,  deficiency
Granulocyte-Macrophage Colony-Stimulating Factor / blood*
Humans
Infant, Newborn
Infant, Very Low Birth Weight / blood*
Male
Neutropenia / blood*
Pre-Eclampsia / blood*
Pregnancy
Chemical
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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