| Evaluation of serum and gingival crevicular fluid C-reactive protein and IL-6 levels in patients with periodontitis and transient ischemic attacks. | |
| | |
MedLine Citation:
|
PMID: 22203929 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Recent advances have suggested that periodontitis (PD), the paradigm of chronic infection in dental pathology, shares several pathogenic pathways with cardio- and cerebro-vascular disorders (CVD), based on inflammatory mediators including IL-1, IL-6, TNF-α. Aim: To assess pro-inflammatory biomarkers (C-reactive protein - CRP, IL-6) in serum and gingival crevicular fluid (GCF) in patients with PD and with transient ischemic attacks (TIAs). Materials and Methods: Prospective observational study on 143 patients classified as follows: 40 healthy subjects (group A), 50 PD patients (group B) and 53 PD-TIAs patients (group C). The predefined assessment protocol has included: current medical data, risk factors for CRP changes, periodontal status (clinical, orthopantomography, Schei Ruler technique), inflammatory biomarkers (CRP, IL-6). Results: High serum CRP and IL-6 have been reported in both TIAs and PD, while statistically significant increase in GCF CRP only in PD-TIAs (p<0.05). Moreover, both generalized and localized chronic PD may be at higher risk for CVD, since CRP level was higher in these subgroups. However, no significant differences were reported in serum IL-6 between generalized and localized PD. A score function was demonstrated, including bone loss degree, bleeding index, collection site depth, serum and GCF IL-6 and CRP, tooth loss, allowing the classification of PD based on risk for developing TIAs. Conclusions: CRP and IL-6 are commonly involved in the pathways of PD and TIAs. Interdisciplinary assessment should be promoted in order to implement the stratification of PD patients according to the risk for TIAs as suggested by the proposed algorithm. |
| | |
Authors:
|
Danisia Haba; Silvia Teslaru; Didona Ungureanu; Diana Hodorog; C Alecu; Ana Gabriela Benghiac; L Zetu; Codrina Ancuţa; E Ancuţa; A Nemţoi; Cristina Iordache |
Related Documents
:
|
15911729 - Bezafibrate for the secondary prevention of myocardial infarction in patients with meta... 15236659 - Risk factors and in-hospital outcomes in stroke and myocardial infarction patients. 17906379 - Impairment of flow-mediated vasodilatation of brachial artery in patients with cushing'... 17087609 - Post-hoc analysis on the cd14 c(-260)t promoter polymorphism and coronary heart disease. 18209769 - Oscillometric measurement of ankle-brachial index. 19745609 - Nonalcoholic fatty liver disease and metabolic syndrome in hypopituitary patients. 19264859 - Abundance of immunologically active alanine aminotransferase in sera of liver cirrhosis... 20975519 - Effects of body weight on tolerability of rivastigmine transdermal patch: a post-hoc an... 9309749 - Internal cardioversion of chronic atrial fibrillation in patients. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Volume: 52 ISSN: 1220-0522 ISO Abbreviation: Rom J Morphol Embryol Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9112454 Medline TA: Rom J Morphol Embryol Country: Romania |
Other Details:
|
Languages: eng Pagination: 1243-7 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania; alexia02ro@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteonecrosis of the jaws associated with the use of bisphosphonates. Discussion over 52 cases.
Next Document: Microscopic aspects of macrophage system cells in hemorrhagic stroke in humans.