Document Detail

Evaluation of serum biomarkers for patients at increased risk of stroke.
MedLine Citation:
PMID:  22506118     Owner:  NLM     Status:  In-Data-Review    
Early recognition of vulnerable patients is an important issue for stroke prevention. In our study, a multiscore analysis of various biomarkers was performed to evaluate its superiority over the analysis of single factors. Study subjects (n = 110) were divided into four groups: asymptomatic patients with stable (n = 25) and unstable (n = 36) plaques and symptomatic patients with stable (n = 13) and unstable (n = 36) plaques. Serum levels of MMP-1, -2, -3, -7, -8, -9, TIMP-1, -2, TNF-α, IL-1b, and IL-6, -8, -10, -12 were measured. Multi-score analysis was performed using multiple receiver operating characteristics (ROC) and determination of appropriate cutoff values. Significant differences between the groups were observed for MMP-1, -7, -9 and TIMP-1 in serum of the study subjects (P < 0.05). Multiple biomarker analysis led to a significant increase in the AUC (area under curve). In case of plaque instability, positive predictive value (PPV) for up to 86.4% could be correctly associated with vulnerable plaques. Thus, multiscore analysis might be preferable than the use of single biomarkers.
Pelisek Jaroslav; Reeps Christian; Ockert Stefan; Zimmermann Alexander; Peter Zepper; Poppert Holger; Eckstein Hans-Henning
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Publication Detail:
Type:  Journal Article     Date:  2012-03-15
Journal Detail:
Title:  International journal of vascular medicine     Volume:  2012     ISSN:  2090-2832     ISO Abbreviation:  Int J Vasc Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101542608     Medline TA:  Int J Vasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  906954     Citation Subset:  -    
Clinic of Vascular Surgery, Klinikum Rechts der Isar der Technischen Universitaet Muenchen, Ismaninger Straße 22, 81675 Munich, Germany.
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