Document Detail

Evaluation of serological cross-reactivity between antibodies to Plasmodium and HTLV-III/LAV.
MedLine Citation:
PMID:  2874279     Owner:  NLM     Status:  MEDLINE    
Serum samples from 460 patients with existing or previous Plasmodium infections, high antimalarial antibody titres, and no apparent risk of exposure to human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) were assayed for HTLV-III/LAV antibody; only 1 sample, from a 21-year-old African woman, was strongly reactive by enzyme-linked immunosorbent assay (ELISA) and positive by western blot. Conversely, no sample from 100 HTLV-III/LAV-positive American homosexual men was strongly reactive for antibodies to the four Plasmodium species that infect human beings by an indirect fluorescent antibody technique, or for antibodies to Plasmodium falciparum by an ELISA technique. Thus, exposure to Plasmodium does not result in HTLV-III/LAV seropositivity, and HTLV-III/LAV antibodies are not strongly cross-reactive with malarial antigens.
A E Greenberg; C A Schable; A J Sulzer; W E Collins; Phuc Nguyen-Dinh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-9     Citation Subset:  AIM; IM; X    
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MeSH Terms
Acquired Immunodeficiency Syndrome / immunology
Antibodies / immunology*
Antibodies, Viral / immunology*
Child, Preschool
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
HIV Antibodies
Malaria / immunology
Middle Aged
Plasmodium / immunology*
South America
United States
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Viral; 0/HIV Antibodies

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