| Evaluation of selected peripheral blood leukocyte functions in patients with various forms of periodontal disease. | |
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MedLine Citation:
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PMID: 15247888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Periodontitis (P) is an infectious disease that develops in the supporting tissues of the tooth. One of the risk factors leading to it may be dysfunction of some immune system cells. Therefore, the object of the study was to assess selected functions of peripheral blood leukocytes in patients with various forms of P. As leukocytes are able to secrete interleukin (IL)-4 and IL-6, concentrations of their soluble receptors and the expression of their membrane receptors were investigated. MATERIAL AND METHODS: Twenty generally healthy subjects with aggressive (AP)and chronic periodontitis (CP)were enrolled in the study. The control group consisted of 8 healthy subjects,with no changes in periodontium. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured. Levels of IL-4,IL-6,and their soluble receptors sIL-4R and sIL-6R were determined in the supernatant by ELISA. The expressions of cell surface IL-4R and IL-6R were assayed on PBMC using flow cytometry. RESULTS: No statistically significant differences were found in the selected parameters between people with periodontal disease and healthy controls. However, in subjects with AP, there was an increasing tendency in IL-6 concentration and IL-4R expression on PBMCs. CONCLUSIONS: Our results show that leukocytes play a significant part in P and their activity is probably lesion-dependent. Estimation of the cytokines secreted by leukocytes may facilitate differentiation and prognosis of the disease progression. |
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Authors:
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Małgorzata Pietruska; Janusz Zak; Jolanta Wysocka; Barbara Jaworowska; Beata Zelazowska; Alina Lipska; Wanda Stokowska |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: 52 ISSN: 0004-069X ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 2004 May-Jun |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2005-03-29 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: Poland |
Other Details:
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Languages: eng Pagination: 208-12 Citation Subset: IM |
Affiliation:
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Department of Conservative Dentistry, Medical Academy, Białystok, Poland. stomzach@amb.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Interleukin-4 / blood, immunology Interleukin-6 / blood, immunology Leukocytes, Mononuclear / immunology* Middle Aged Periodontal Diseases / blood*, immunology* Receptors, Interleukin-4 / blood, immunology Receptors, Interleukin-6 / blood, immunology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Receptors, Interleukin-4; 0/Receptors, Interleukin-6; 207137-56-2/Interleukin-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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