| Evaluation of the screening power of Cognitive Abilities Screening Instrument for probable Alzheimer's disease using voxel-based morphometry. | |
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MedLine Citation:
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PMID: 22226443 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to compare two screening methods, total score of the Cognitive Abilities Screening Instrument (CASI(T)) and the combined score for the short-term memory and orientation domains (CASI(R)) for screening and grading probable Alzheimer's disease (AD), based on their correlations with voxel-based morphometry (VBM). MATERIALS AND METHODS: Forty-five subjects with probable AD and normal controls underwent magnetic resonance imaging and CASI testing. Their corresponding T1-weighted magnetic resonance images were analyzed using VBM. RESULTS: VBM results showed that in moderate-to-severe AD subgroups, significant whole-brain gray matter loss was detected using both CASI(T) and CASI(R). Significantly more voxels were detected using the CASI(T) compared with the CASI(R) system in mild AD subjects (P<.05). CONCLUSIONS: Based on their correlations with VBM results, there is no significant difference for CASI(R) and CASI(T) for grading moderate-to-severe AD subgroups, and CASI(R) scoring system may be more accurate and effective than the CASI(T) for screening mild AD. |
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Authors:
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Greta S P Mok; Yi-Ying Wu; Kun-Mu Lu; Jay Wu; Liang-Kuang Chen; Tung-Hsin Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical imaging Volume: 36 ISSN: 1873-4499 ISO Abbreviation: Clin Imaging Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911831 Medline TA: Clin Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 46-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Macau. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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